Lck kinase fine-tunes T cell activation by phosphorylating autophagy receptor p62
A new EMBO Reports study shows that the kinase Lck phosphorylates the autophagy receptor p62 at tyrosine 433 within minutes ...
Tag: Interleukin 2
Gene brake ZMYND8 drives T-cell exhaustion and blocking it may strengthen immunotherapy
St. Jude scientists found that deleting the gene ZMYND8 relieves CD8-positive T-cell exhaustion and synergizes with immunotherapy to improve anti-tumor ...
UChicago Medicine Trials Homegrown Engineered T-Cell Therapy for Advanced Solid Tumors
UChicago Medicine has launched a first-of-its-kind investigator-initiated clinical trial of a fully on-site manufactured T-cell receptor therapy engineered to target ...
Cell Therapy Takes Aim at Rare Nerve Tumors in New Preclinical Breakthrough
Researchers have developed an optimized tumor-infiltrating lymphocyte manufacturing protocol that shows preclinical efficacy against NF1- and schwannomatosis-related nerve sheath tumors, ...
Lab-Grown B Cells Reveal Why Immune Defenses Falter in Common Variable Immunodeficiency
Researchers in Madrid have developed an in vitro stimulation model showing that B cells from patients with common variable immunodeficiency ...
Clinical Risk Scores Cannot Stand In for Neurofilament Biomarkers in ALS Trials, Study Finds
A reanalysis of the MIROCALS trial shows that the TRICALS clinical risk score adds useful prognostic information in ALS but ...
Engineered Tolerance: Can CAR-Tregs Reset the Immune System in Vasculitis?
A new review in the Journal of Translational Medicine maps the evidence linking regulatory T cell dysfunction to vasculitis and ...
Preoperative Interleukin 2: Impact on Cancer Surgery Outcomes
Recent advancements in immunotherapy have generated considerable interest within the scientific community, particularly in the context of cancer treatment. One ...
