Trojan Horse Inhibitors Slip Through Gasdermin Pores to Shut Down Pyroptosis
New research shows that gasdermin D pores formed during pyroptosis can admit selectively designed caspase inhibitors, allowing the inflammatory cell ...
New research shows that gasdermin D pores formed during pyroptosis can admit selectively designed caspase inhibitors, allowing the inflammatory cell ...
A large longitudinal study shows that DNA methylation-based biological aging and the cytokine TGF-beta play distinct causal roles in cognitive ...
A study of 984 rheumatoid arthritis patients finds that the Prognostic Nutritional Index, a simple blood-based score combining albumin and ...
New research shows that neutrophil extracellular traps driven by high blood sugar worsen bleeding complications after ischemic stroke, and that ...
A new study identifies the E3 ubiquitin ligase HERC4 as the long-sought molecular switch that licenses RIPK1 to initiate TNF-induced ...
A new NHANES-based study of 11,668 US adults finds that a higher red blood cell distribution width-to-albumin ratio is independently ...
A new commentary in Pediatric Research evaluates whether the Aggregate Index of Systemic Inflammation, calculated from routine blood count parameters, ...
A study of 420 Brazilian adults links variants in ADRB3, LEPR, FTO and PPARG to metabolic syndrome and shows that ...
A new review in Medical Oncology argues that gut microbial dysbiosis drives systemic inflammation that contributes to both type 2 ...
Protein structure prediction has revealed an ancient family of IL-1 cytokines spanning cnidarians to vertebrates, indicating that the inflammatory IL-1/IL-1R ...
A rat study shows that prenatal exposure to preeclampsia produces lasting anxiety, prolonged cortisol stress responses, and—in males only—depression-like behavior ...
A cross-sectional study of 304 Turkish preschoolers found that children with higher dietary intake of advanced glycation end products had ...
A study of 156 patients in Xinjiang, China, links a specific KSHV K15 gene variant to aggressive Kaposi sarcoma through ...
Researchers combined mouse experiments, network pharmacology, and molecular docking to show that the traditional Chinese medicine Zhike Pipa Granules relieve ...
A Mayo Clinic study of irradiated mice shows that males develop inflammatory dilated cardiomyopathy and fibrosis after cardiac radiation while ...
A population-based study of 1,769 Swedish older adults links Mediterranean-style and low-inflammatory diets to favorable blood biomarker profiles spanning metabolic, ...
New research shows that the immune surface protein CD37 drives inflammatory macrophage activity that impairs blood vessel regrowth and muscle ...
A new narrative review in Reproductive Sciences argues that gut microbial dysbiosis, endotoxemia, and chronic low-grade inflammation drive insulin resistance ...
MSK scientists identified the long-unknown enzyme behind the inflammatory signal 5-oxoETE and discovered that the pathway also protects healthy cells ...
A new rat study shows that the FAAH inhibitor URB597 protects kidneys from sepsis-associated injury by suppressing inflammation, apoptosis, and ...
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