Dendritic cells and regulatory T cells reinforce immunosuppression in pancreatic tumors
Single-cell and spatial profiling of pancreatic tumors reveals a reinforcing loop between mature dendritic cells and regulatory T cells, mediated ...
Tag: immunosuppression
New Automated qPCR Assay Shows TTV Viral Loads Fluctuate Naturally Over Time
A newly developed, analytically validated automated qPCR assay for Torque teno virus DNA achieved a limit of detection of 32.3 ...
Research report: Immunological signatures of sepsis in abdominal solid organ transplant recipients: A multilayer and multicentric prospective cohort study
A multicenter prospective cohort analysis finds that septic abdominal solid organ transplant recipients show better 30-day survival and a distinct ...
Kidney transplant recipients in Thailand face sharply elevated cancer risk, study finds
A Thai single-center cohort study of 292 kidney transplant recipients found 6.8 percent developed de novo malignancies, with urothelial cancer ...
Antiviral Drug Valganciclovir Linked to Reversible Azoospermia in Transplant Patient
A French case report links valganciclovir, a cytomegalovirus prophylaxis drug given after liver transplantation, to reversible azoospermia and documents the ...
Tegoprubart beats tacrolimus on kidney function and quality of life in BESTOW trial
Phase 2 BESTOW trial results show tegoprubart preserved kidney function better than tacrolimus and improved patient-reported quality of life in ...
Immune Risk Profile Flags BK Virus Reactivation After Living Donor Kidney Transplant
A prospective Swedish study found that a low pre-transplant CD4/CD8 ratio combined with cytomegalovirus seropositivity was associated with later BK ...
Early azathioprine in autoimmune hepatitis shows no clear extrahepatic cancer risk in Korean cohort
A nationwide Korean claims cohort of 8,280 patients with autoimmune hepatitis found no statistically significant association between early azathioprine prescription ...
Rare EBV-Positive Lymphoma Masqueraded as Advanced Mycosis Fungoides Progression
A Japanese case report describes EBV-positive diffuse large B-cell lymphoma arising during advanced mycosis fungoides and mimicking disease progression.
Empirical antiparasitic prophylaxis proposed for immunosuppressed rheumatic disease patients
A narrative review proposes ivermectin-based empirical antiparasitic prophylaxis, combined with albendazole or nitazoxanide, for selected immunosuppressed patients with rheumatic diseases ...
Skin Biopsy Revealed Fatal Fungal Trigger of Hyperinflammation When Marrow Testing Failed
A case report describes how biopsy of subtle forehead papules identified Histoplasma capsulatum in a fatal case of HLH despite ...
PLA2G2A fuels gallbladder cancer stemness and immune suppression
A new Cellular Oncology study shows that the enzyme PLA2G2A drives gallbladder cancer progression by promoting cancer stemness through PLA2R1, ...
Chest CT patterns in Pneumocystis pneumonia vary with immune status and co-infection
A retrospective ICU study of 106 patients found that chest CT patterns in Pneumocystis jirovecii pneumonia differ according to the ...
Heart Transplantation Offers Acceptable Long-Term Survival in Chagas Heart Disease
An individual patient data meta-analysis of 305 Chagas heart disease transplant recipients reports acceptable long-term survival and observational associations between ...
Resistant Melanoma Cells Recruit Immune Cells to Thwart Targeted Therapy
BRAF inhibitor-resistant melanoma cells release M-CSF and remodel the immune microenvironment, and blocking this signal improved drug efficacy in mouse ...
How Regulatory T Cells Help Ovarian Cancer Hide From the Immune System
A new review explains how regulatory T cells are co-opted by ovarian tumors to suppress immunity, and how precision therapies ...
Many Latin American Arthritis Patients Skip Tuberculosis Screening Before Immunosuppressive Drugs
A prospective PANLAR registry study found 27% of Latin American patients with chronic inflammatory arthritis started DMARDs without tuberculosis infection ...
Tumor acidity emerges as a metabolic barrier blocking cancer immunotherapy
A narrative review argues that the acidic tumor microenvironment suppresses antitumor immunity and that targeting acidity is a preclinically supported ...
Foscarnet Resolves Refractory Anemia in Lupus Patient With Parvovirus B19
A case report describes a woman with lupus and autoimmune hemolytic anemia whose parvovirus B19-driven pure red cell aplasia responded ...
Kidney transplant stone treatment outcomes rest on shaky evidence, review finds
A scoping review finds that stone-free rates for minimally invasive treatment of kidney transplant stones rest on a single pooled ...
