BRCA1 and HRR Variants Linked to Improved Survival in Brazilian Triple-Negative Breast Cancer
A study of Brazilian triple-negative breast cancer patients found improved progression-free survival in carriers of BRCA1 and HRR variants alongside ...
Tag: homologous recombination deficiency
Review Outlines How Oxidative Stress and DNA Damage Expose Cancer Vulnerabilities
A scientific review highlights how oxidative stress drives cancer progression while exposing therapeutic vulnerabilities that can be targeted through synthetic ...
Rare breast cancer subtype shows poor outcomes and distinct genomic profile
A study of 77 patients found matrix-producing metaplastic carcinoma of the breast is marked by frequent germline HRD gene variants, ...
Replication stress marker points to ovarian cancers that may yield to ALC1 targeting
New research shows that removing the chromatin remodeler ALC1 sensitizes a broad range of ovarian cancer models to PARP inhibitors ...
Neural network reads cancer’s mutational fingerprints from tiny data scraps
A supervised neural network called SuRe outperforms established methods at inferring mutational signature exposures from sparse cancer sequencing data, including ...
Deep learning predicts DNA repair deficiency in HGSOC pathology slides
A retrospective study in high-grade serous tubo-ovarian carcinoma found that HRDPath inferred homologous recombination deficiency from pathology slides with an ...
BRCA1 Carriers Respond Better to Breast Cancer Chemotherapy, Landmark Chinese Study Finds
A study of 1,009 Chinese breast cancer patients found that BRCA1 mutation carriers had far higher rates of complete tumor ...
Platinum Chemotherapy, Not PARP Inhibitors, Emerges as the Main Driver of Blood Clone Expansion
New research shows carboplatin drives the expansion of TP53-mutant blood clones far more strongly than PARP inhibitors, while inherited homologous ...
Pan-Cancer Study Reveals DNA Repair Defects
A groundbreaking pan-cancer study published in BMC Cancer unveils the intricate landscape of homologous recombination deficiency (HRD) and homologous recombination ...
