Ustekinumab Shows Promise for Perianal Fistulizing Crohn’s Disease, Review Finds
A narrative review synthesizes trial and real-world evidence suggesting ustekinumab can drive fistula healing in Crohn's disease, especially when combined ...
Tag: Gastroenterology
Diet plus biologics eased symptoms faster in children with Crohn’s disease, but inflammation lagged
A retrospective pediatric cohort study found that adding the Crohn's disease exclusion diet with partial enteral nutrition to first-line biologic ...
Plecanatide Meta-Analysis Finds 3 mg Best Balances Constipation Relief and Safety
A meta-analysis of 15 randomized trials finds plecanatide significantly improves bowel function in chronic idiopathic constipation and IBS-C, with 3 ...
Muscle Loss Signals Higher Hospitalization Risk in People With Inflammatory Bowel Disease
A prospective Italian cohort of 113 patients with inflammatory bowel disease found that confirmed sarcopenia was independently associated with IBD-related ...
MRI and Ultrasound Disagree on Crohn’s Disease Measurements, Major Study Finds
A large multicentre analysis of the METRIC trial found that MR enterography and intestinal ultrasound agree well on a global ...
Digestive Enzyme Combination Eased Functional Dyspepsia Symptoms in 12-Day Indian Study
A 12-day, single-arm Indian study of 160 adults with functional dyspepsia reported a 98.4% mean symptom-score improvement with a papain ...
AI Chatbots Answer Gastric Cancer Questions but Struggle to Spot It in Endoscopy Images
Large language models performed well on written early gastric cancer questions but showed limited and inconsistent ability to recognise the ...
Eluxadoline Dispensing in Medicare Peaked in 2018, Then Fell as Costs Climbed
A national analysis of Medicare Part D data found eluxadoline dispensing peaked in 2018 and declined thereafter, with geographically concentrated ...
Simple Stool Test Flags Hidden Gut Inflammation in Eye Disease Patients
A prospective Spanish cohort study found that persistently elevated serial fecal calprotectin measurements identified subclinical ileitis in a small subgroup ...
Blood Tests and Endoscopy Combine to Predict Ulcerative Colitis Without Calprotectin
A retrospective multicenter study in China found fecal calprotectin was documented in only 0.9 percent of 655 patients, prompting a ...
Three Baseline Gene-Expression Endotypes Track With Healing in Ulcerative Colitis
An integrative reanalysis of 778 baseline mucosal transcriptomes from public ulcerative colitis cohorts identified three gene-expression endotypes that stratify healing ...
Probiotics Ease Side Effects of Vonoprazan-Based H. pylori Therapy, Review Finds
A strict meta-analysis of nine randomized trials finds that adjunctive probiotics probably reduce adverse events during vonoprazan-based Helicobacter pylori eradication ...
Low fecal elastase in immunotherapy diarrhea may reflect dilution, not pancreatic insufficiency
A retrospective study of 388 patients suggests that low fecal elastase in immune checkpoint inhibitor-related diarrhea is more likely a ...
Inflammation Blood Index Linked to Iron Deficiency in Adult Celiac Disease
A study of 120 adults with celiac disease found that higher systemic immune-inflammation index values were associated with ferritin deficiency, ...
Gut Before Skin: IBS Tends to Precede Rosacea in Landmark Timing Study
A new analysis of 1,421 patients with both conditions finds irritable bowel syndrome is typically documented before rosacea, a pattern ...
Rare Ampullary Neuroendocrine Tumors Yield Their Secrets in 14-Year Global Case Review
A systematic review pooling 32 cases of ampullary neuroendocrine tumors from 2010 to 2024 reveals diagnostic, treatment, and prognostic patterns ...
One in Twelve Asian Children May Have Functional Constipation, Major Review Finds
A meta-analysis of 17 studies covering more than 175,000 young people estimates that 8 percent of Asian children and adolescents ...
Doctors Think They Share Decisions With IBD Patients. Patients Disagree, Study Finds
A Belgian qualitative study of patients, gastroenterologists, and IBD nurses reveals a persistent gap between clinicians' belief that they practice ...
$4 Million NIH Grant Targets Lingering Gut Symptoms When Colitis Inflammation Fades
A $4 million NIH-funded five-year study led by UCLA Health and Mount Sinai will investigate why IBS-like symptoms persist in ...
AI Scoring of Stomach Lining Visibility Boosts Early Cancer Detection in Landmark Trial
A new artificial intelligence system that measures how much stomach lining endoscopists actually see is strongly linked to higher detection ...
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