Semi-automated motility assay speeds the hunt for new liver fluke drugs
A new semi-automated imaging assay that monitors the motility of Fasciola hepatica juveniles identified three nanomolar-potent salicylanilide hits, though only ...
Tag: Fasciola hepatica
Research report: Spatial lipidomics of Fasciola hepatica using high-resolution AP-SMALDI Orbitrap MSI – a lipid tissue atlas
High-resolution mass-spectrometry imaging mapped distinct lipid distributions across the tegument, intestine, ovary and testis of the common liver fluke in ...
Liver Flukes Deploy Tiny Molecular Messengers to Disarm the Host Immune System
A new review synthesizes how extracellular vesicles released by Fasciola liver flukes manipulate host immunity and could guide novel vaccines ...
Proteomics and First CRISPR-Cas9 Editing Point to New Liver Fluke Vaccine Targets
A comparative proteomics pipeline and the first CRISPR-Cas9 gene editing in Fasciola hepatica juveniles have identified three surface-exposed proteins as ...
Climate Change Will Reshape Liver Fluke Risk Unevenly Across Africa and Europe, New Index Shows
A new mechanistic risk index projects that climate change will reduce fascioliasis risk across most of Africa while increasing it ...
Unlocking Fasciola hepatica Kinome for Drug Targets
In the ever-evolving landscape of molecular parasitology, recent advancements have illuminated the potential of targeting the intricacies of the kinome ...
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