Tag: Epithelial-mesenchymal transition

New research shows that the chaperonin subunit CCT2 stabilizes the oncoprotein c-Myc to drive head and neck squamous cell carcinoma ...

New research shows that senescent cancer-associated fibroblasts in high-grade serous ovarian cancer secrete Tenascin-C, which activates SDC4-ERK signaling in tumor ...

Patient-derived organoid and xenograft models reveal that a collagen I-rich tumor matrix activates TGFβ signaling and LTBP2 expression, priming colorectal ...

A new Cell Death Discovery study shows that the two strands of the pre-miR-16-1 microRNA duplex can cooperatively suppress both ...

New research shows that pairing the decades-old antipsychotic chlorpromazine with the mitochondrial fission inhibitor mdivi-1 sharply boosts cancer cell death ...

A comprehensive review in Cell Death Discovery maps how the transcription factor Snail2 governs partial epithelial-mesenchymal transition, driving both embryonic ...

A new review in Medical Oncology argues that gut microbial dysbiosis drives systemic inflammation that contributes to both type 2 ...

A new review explains how tumor cells reversibly switch identities through epigenetic and microenvironmental programs, driving metastasis and therapy resistance.

A new study integrates single-cell transcriptomics with human tissue and mouse model validation to show that TGF-beta/Smad-driven dialogue between epithelial ...

Researchers at Harbin Medical University report that the RNA-binding protein PTBP3 stabilizes SMAD3 mRNA and drives podocyte epithelial-to-mesenchymal transition, and ...

A new review in the Journal of Translational Medicine maps how perineural invasion may drive hepatocellular carcinoma aggression, organizing the ...

Researchers have identified a LAPTM5-WWP2-OPTN mitophagy cascade that drives retinal pigment epithelium senescence and subretinal fibrosis through cGAS-STING activation, with ...

A new review in Cancer Cell International details how cancer-associated fibroblasts remodel the colorectal tumor microenvironment and drive resistance to ...

A large-scale proteomic study of 404 cervical cancer samples has revealed three molecular subtypes of squamous cell carcinoma with distinct ...

In a groundbreaking development that may redefine our understanding of biliary atresia, researchers Balfour-Lynn and Dhawan have spotlighted the enzyme ...

Decoding the Role of Exosomal miR-4669 in Adenomyosis: A Revolutionary Insight In a groundbreaking study published in Reproductive Sciences, researchers ...