CRISPR Screen Points to Autophagy Blockade Plus PARP Inhibitor Against Lung Cancer
A preclinical CRISPR screen found that loss of mTOR-regulating genes sensitizes small cell lung cancer cells to PARP inhibitors, and ...
Tag: Drug synergy
Juniper extract nanoparticles show antimicrobial and anticancer activity in lab tests
Egyptian researchers loaded Juniperus phoenicea leaf extract into nanostructured lipid carriers that showed enhanced antibacterial activity against Acinetobacter baumannii and ...
Microfluidic Gradient Screen Links Drug Combination Responses to Leukaemia Outcomes
A microfluidic platform called GradientScreen generates overlapping drug gradients and its combination response metrics correlate with minimal residual disease and ...
EP300 Degradation and AKT Inhibition Slow Osteosarcoma in Preclinical Models
A PROTAC that degrades EP300 combined with AKT inhibition slowed tumor growth and extended survival in patient-derived osteosarcoma mouse models, ...
Lichen Compound Usnic Acid Supercharges a Key Antifungal Drug in Lab Tests
A new in vitro study finds that the lichen-derived compound usnic acid dramatically enhances posaconazole against drug-resistant fungi through ROS ...
Spirulina pigment dismantles a key shield that blocks breast cancer drug response
A new cell study shows that C-phycocyanin can strip away Mcl-1-driven resistance and make the BH3-mimetic ABT-737 far more lethal ...
Machine Learning Predicts Antibacterial Drug Synergy Without Data Leakage
Researchers developed HALO, a machine-learning framework that predicts antibacterial drug synergy from multi-level bioactivity features while exposing how data leakage ...
REV-ERB Agonist Boosts Sorafenib Against Liver Cancer
In a groundbreaking advance in liver cancer treatment, researchers have identified the metabolic clock protein REV-ERB as a pivotal factor ...
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