Leukemia cells lacking PTEN reveal a metabolic weakness that approved drugs can exploit
Loss of PTEN makes T-cell acute lymphoblastic leukemia cells dependent on the guanylate-synthesis enzyme IMPDH, allowing clinically approved IMPDH inhibitors ...
Tag: DNA replication stress
KCTD10 Detects Co-Directional Transcription-Replication Conflicts
In a groundbreaking study poised to reshape our understanding of how cells preserve genomic integrity during DNA replication, researchers have ...
KAIST Study Suggests Cancer Cell Nuclear Hypertrophy May Inhibit Tumor Spread
In a groundbreaking study that challenges long-held assumptions in oncology, researchers at the Korea Advanced Institute of Science and Technology ...
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