Tag: DNA Methylation

A new narrative review in Pediatric Research reframes bronchopulmonary dysplasia as a disorder of epigenetic programming in which hyperoxia, inflammation ...

A massive Hi-C study across eight mouse strains shows that the strength of chromatin boundary insulation predicts how faithfully topologically ...

A large postmortem study identified 107 brain DNA methylation sites linked to Alzheimer's pathology and showed that methylation partially mediates ...

A comprehensive review in Diabetes Therapy maps the bidirectional relationship between diabetes and cancer, positioning epigenetic dysregulation as the molecular ...

A new review in Molecular Biology Reports argues that DNA methylation silencing of the TRAIL pathway components DR5, DcR2, and ...

A comprehensive pan-cancer study identifies the ribosome biogenesis enzyme DIMT1 as a prognostic and immune-associated biomarker whose depletion suppresses gastric ...

A paired-sample study of 38 melanoma patients reveals that metastases undergo coordinated DNA methylation reprogramming largely independent of driver mutations, ...

A new Aging Cell study shows that single-clock reports of biological age reversal often fail when tested against multiple epigenetic ...

A new data-driven dietary index built around epigenetic aging clocks is associated with nearly four years slower biological aging, lower ...

A Johns Hopkins study shows chronic cigarette smoke exposure reprograms distinct lung stem cell populations through epigenetic changes, determining whether ...

A retrospective study of 170 patients finds that synchronous chemoradiotherapy significantly extends survival in muscle-invasive urothelial carcinoma, while methylation of ...

A study of nearly 900 dogs in the Dog Aging Project shows that larger and male dogs undergo accelerated epigenetic ...

A two-stage epigenome-wide meta-analysis of more than 2,000 individuals has identified thousands of DNA methylation sites where Parkinson's disease affects ...

A large-scale study of 864 dogs finds that giant breeds lose methylation control over LINE1 jumping genes far faster than ...

A new GeroScience study finds that after sexual maturity, housekeeping genes lose transcriptional share to specialized integrative genes across species, ...

Researchers have discovered that DNA methylation evicts the architectural protein CTCF from the HOXD locus, collapsing a chromatin loop that ...

A large two-cohort study shows that a blood-based DNA methylation panel targeting the HYAL2, S100P and DYRK4 genes, combined with ...

A large longitudinal study shows that DNA methylation-based biological aging and the cytokine TGF-beta play distinct causal roles in cognitive ...

A cross-species single-cell epigenome atlas shows that kidney disease accelerates epigenetic aging most dramatically in tubular epithelial cells, which lose ...

The first Hi-C analysis of the tiny alga Ostreococcus tauri shows that its enigmatic low-GC outlier chromosomes fold into sharply ...