CRISPR–Cas systems in Microcoleus cyanobacteria show a dynamic history of gene flow
A new study of 14 Microcoleus species finds that CRISPR–Cas systems are widespread but do not follow species phylogeny, pointing ...
Tag: CRISPR
Prophages Shape Virulence, Not Resistance, in Staphylococcus aureus Genomes
A population-scale genomic survey of 1,678 Staphylococcus aureus genomes finds intact prophages frequently carry virulence genes but rarely antimicrobial resistance ...
Only Two Soil Cleanup Approaches Actually Work in the Field, Review Finds
A new mini-review finds that only metal immobilization and hydrocarbon rhizoremediation by cultured consortia have been field-validated, while microplastic remediation ...
Knocking Out MAX1 Rewires Leaf Senescence in Lettuce Toward a Stress State
Deleting the strigolactone biosynthesis gene MAX1 in lettuce produces a strong stay-green phenotype in darkness while redirecting part of the ...
Serovar 13 Glaesserella parasuis strain shows marked pathogenicity in piglet challenge model
A clinical Glaesserella parasuis serovar 13 isolate caused dose-dependent mortality in a piglet challenge model, and whole-genome sequencing revealed putative ...
Scientists decode full genome of probiotic bacterium from Japanese pickled Chinese yam
Researchers report the complete genome of Lacticaseibacillus paracasei TOKAI 83 m, a heavy-metal-binding probiotic candidate isolated from pickled Chinese yam ...
CRISPR-based LAMP assays detect tuberculosis with high accuracy in early study
Two LAMP-CRISPR diagnostic pipelines for Mycobacterium tuberculosis reached a limit of detection of 10 copies per microlitre, with the Cas12a ...
Nigerian Stool Culture Yields Complete Genome of Opportunistic Pathogen Acinetobacter pittii
A complete metagenome-assembled genome of Acinetobacter pittii ST640, recovered from a human stool-derived mixed culture in Nigeria, reveals intrinsic resistance ...
CRISPR gene therapies face a reckoning with off-target genome edits
A new review maps the molecular, computational and experimental landscape of off-target CRISPR editing as gene therapies advance toward the ...
AI-Designed Gene Editor Helps Rice Resist Bacterial Blight
University of Missouri researchers used the AI-designed, open-source gene editor OpenCRISPR-1 to create rice plants that resist bacterial blight, with ...
Loss of CDH1 rewires mammary cell identity toward a luminal progenitor state
Genetic loss of CDH1 remodels human mammary epithelial cells toward a luminal progenitor-like state, modeling an early step in invasive ...
CRISPR methylation biosensors for liquid biopsy: powerful chemistry, thin clinical evidence
A new review maps four molecular routes by which CRISPR systems can detect cancer-linked DNA methylation in cell-free DNA, and ...
Gladstone Scientists Melanie Ott and Alex Marson Join National Academy of Medicine
Gladstone Institutes physician-scientists Melanie Ott and Alex Marson have been elected to the National Academy of Medicine in recognition of ...
Aptamers Emerge as Programmable Building Blocks for Precision Cancer Immunotherapy
A new review maps how engineered DNA and RNA aptamers could enable targeted delivery and tumor microenvironment remodeling in precision ...
Germline Stem Cell Transplantation Could Scale Up Genome Editing in Farmed Fish
A review argues that editing germline stem cells in culture and transplanting them into sterile surrogates could overcome the scalability ...
CRISPR promoter editing trims rice stomata to boost water efficiency with a yield trade-off
Scientists edited the promoter of the rice gene OsGTL1 to lower stomatal density, raising instantaneous water use efficiency while revealing ...
Plants Wage Chemical Warfare Against Pathogens, and Scientists Are Learning to Weaponize It
A comprehensive review maps how plants deploy bioactive compounds against pathogens and outlines genetic, nanotech and microbiome strategies to engineer ...
Bibliometric review finds genome editing missing from Ficus research landscape
A systematic bibliometric analysis of 25 years of Ficus literature shows that only about 11.3 percent of publications address genomic ...
Review finds CRISPR maternal–infant diagnostics not yet clinically ready
A structured review found that CRISPR diagnostics for maternal–infant HIV, hepatitis B and syphilis care remain clinically unready, with HIV ...
The potential of metabolic engineering for sustainable phytosterol production
A 2026 review synthesizes plant, enzyme-engineering and microbial approaches to phytosterol production, including a reported engineered-yeast campesterol titer of 5.88 ...
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