Tag: clonal hematopoiesis

A review of liquid biopsy approaches highlights the emerging capacity of circulating tumor DNA to detect residual disease and track ...

A scientific review details how epigenetic mechanisms influence complement system activity and tissue vulnerability across context-dependent stages of biological aging.

A comprehensive review details how somatic mutations in blood stem cells infiltrate solid tumors and influence local immune responses and ...

A comprehensive review examines circulating tumor DNA across solid tumors, highlighting its prognostic accuracy in minimal residual disease alongside key ...

A standalone computational framework called CREMA detects high clonal fraction mosaic chromosomal alterations that are frequently missed by phase-based genomic ...

A comprehensive genomic atlas of 1,429 Chinese individuals identifies novel phenotype-associated loci and structural variants modulating clinical heterogeneity in β-thalassemia.

A scientific review identifies clonal hematopoiesis as a measurable biological bridge connecting toxic environmental exposures to long-term health risks.

A retrospective cohort study in Blood Research finds that clonal hematopoietic mutations are independently associated with increased risks of chronic ...

A brief report outlines the clinical, laboratory, and disclosure challenges that occur when post-transplant recipient sequencing detects genetic variants originating ...

Researchers documented a rare case of Epstein–Barr virus-positive nodal T follicular helper cell lymphoma that evolved through stepwise genetic mutations ...

A mouse and patient study finds that hematopoietic loss of the X-linked gene KDM6A worsens cardiac recovery after myocardial infarction ...

A targeted deep sequencing method simultaneously estimates mosaic Y chromosome loss and CHIP-related mutations, validated in over 400 male patients ...

A cross-sectional analysis of 2,994 Korean whole-genome sequencing participants identified clonal hematopoiesis in 3.11%, rising with age and most often ...

A Phase II trial in Japan identified TCR signaling mutations and clonal hematopoiesis burden as biomarkers predicting dasatinib response in ...

A new perspective examines a recent study reporting that telomeres in mouse tails and leukocytes do not shorten with age, ...

A retrospective Korean study found that combining sequencing-based residual disease testing with donor chimerism assessment three months after transplant stratified ...

A peer-reviewed review proposes that chronic DNA damage response signaling may connect senescence, inflammation and other aging processes, while emphasizing ...

A case report and literature review describe acute myeloid leukemia developing 32 months into icotinib therapy for EGFR-mutated lung cancer, ...

A sweeping review of population-scale genomic data reveals that loss of the X chromosome is the most common mosaic chromosomal ...

The practical framework outlined by Zhang and Madlensky arrives at a moment when the infrastructure of precision oncology is being ...