Study Pinpoints Ropivacaine Dose and Positioning Time for One-Sided Spinal Anesthesia
A sequential dose- and time-finding trial determined the median effective dose of 0.5% hyperbaric ropivacaine and the median lateral decubitus ...
Tag: clinical trial
Long-Term Trial Data Show Triplet Therapy Extends Survival in Metastatic Prostate Cancer
Long-term PEACE-1 trial results show that adding abiraterone to ADT and docetaxel reduced the risk of death by 32 percent ...
First-in-Human Trial Uses Laser Light to Attack Inoperable Pancreatic Tumors
A first-in-human phase 1 trial at UCI Health is using padeliporfin vascular-targeted photodynamic therapy to destroy pancreatic tumors encasing major ...
Intensive Group Therapy Shows Promise for Children with Selective Mutism in Pilot Trial
A pilot study of fifteen German children with selective mutism found large reductions in parent-rated symptom severity and a remission ...
Cancer genome profiling uncovers hidden inherited cancer risk in one in ten patients
A prospective trial found constitutional pathogenic variants in about 10 percent of solid tumor patients screened through comprehensive cancer genome ...
Ketone Ester Shows Early Biomarker Signals in ALS Trial
A randomised German trial found oral D-β-hydroxybutyrate ester was well tolerated in ALS patients and showed preliminary adjusted effects on ...
Pantethine supplement shows promise against psoriasis in mice and small trial
A vitamin B5 derivative called pantethine suppressed dendritic cell hyperactivation, prevented psoriasis in mice and improved symptoms in a small ...
Wrist Acupoint Injection of Granisetron Outperforms IV Route Against Postoperative Nausea in Trial
A randomized controlled trial in gynecological laparoscopic surgery patients found that injecting granisetron at the PC6 wrist acupoint significantly reduced ...
Phase 3 Trial: New Drug Cuts Endometrial Cancer Death Risk
A phase 3 trial shows sacituzumab tirumotecan significantly lowers the risk of cancer progression and death in women with recurrent ...
First Placebo-Controlled Trial Will Test Prednisone for Drug-Induced Liver Injury
The DILICORT trial, the first randomized double-blind placebo-controlled study of prednisone in acute idiosyncratic drug-induced liver injury, will enroll sixty ...
UCLA researchers receive NIH grant to launch trial for immunotherapy-related diabetes
An NIH-funded phase 1/2 trial will test whether JAK inhibitors can protect pancreatic insulin-producing cells in people who develop diabetes ...
Mindfulness and Tai Chi Ease Pain, Fatigue, and Sleep Problems After Cancer Treatment
A clinical trial of more than 500 cancer survivors found that mindfulness and tai chi or qigong improved pain interference, ...
PATHFINDER 2 trial finds 6.5-fold more cancers with blood test
The 35,878-person PATHFINDER 2 trial found 6.5-fold more cancers when Galleri was added to routine screening, but it did not ...
Low-dose prednisolone eases long-COVID symptoms modestly, but B vitamins fail in phase 3 trial
In the first randomised placebo-controlled phase 3 factorial trial for post-COVID-19 syndrome, a 28-day course of low-dose prednisolone significantly reduced ...
First US patients in pulmonary artery denervation trial
Henry Ford Health has enrolled the first US patients in a global clinical trial evaluating pulmonary artery denervation for pulmonary ...
Accelerated FDA approval for dostarlimab in biomarker-defined locally advanced rectal cancer
The FDA granted accelerated approval for dostarlimab in adults with stage II or III locally advanced rectal cancer whose tumors ...
BabyMERIT Trial to Test Trametinib for Severe Infantile Hypertrophic Cardiomyopathy
The NIH-funded BabyMERIT trial will test trametinib in 25 infants with severe hypertrophic cardiomyopathy associated with Noonan syndrome and related ...
Centella mouthwash shows no significant benefit after wisdom tooth surgery
A 36-participant randomized trial found no statistically significant clinical benefit from 0.12% Centella asiatica mouthwash after mandibular third molar surgery.
Thai researchers outline early-phase trial of a new GD2 CAR-T product
A published protocol describes a planned first-in-human trial of an investigational product: an autologous chimeric antigen receptor T-cell therapy designed ...
Landmark Trial Tests Whether Chemotherapy Can Be Spared in High-Risk Early Breast Cancer
The new phase 3 RxFINE-Low trial will test whether patients with low genomic risk but high anatomic risk early-stage breast ...
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Depression Stigma Scale Demonstrates Reliability in Kazakh and Russian Validation Study
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Five AI Models Evaluated for Irritable Bowel Syndrome Patient Information
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Childhood income trajectories shape depression and anxiety risk differently in immigrant families
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Study Genetically Prioritizes Plasma Proteins Across Diverse Clinical Subtypes of Dementia