Machine Learning Identifies Three ALS Progression Patterns
A new machine learning framework identifies three distinct progression patterns in ALS patients, offering a tool for earlier prognostic assessment ...
Tag: Clinical trial design
How Traditional Chinese Medicine Clinical Trials Can Achieve Global Credibility
Researchers have outlined the essential evidence-based methodological requirements and trial designs necessary for traditional Chinese medicine to achieve international credibility.
TACMONO-XL trial to test whether tacrolimus monotherapy can cut infections in older kidney transplant recipients
A new study protocol details the TACMONO-XL trial, which will randomize 306 kidney transplant recipients aged 60 and older to ...
Platform Trials Promise Faster Answers but Face Serious Methodological Pitfalls
A new review finds adaptive platform trials offer real efficiency gains but are often undermined by weak blinding, non-concurrent controls ...
Implementation Science Principles Shape Scalable Early Therapy for Infants at Risk of Motor Delay
Researchers embedded implementation science principles into an ongoing infant physical therapy trial to make early neuromotor interventions ready for rapid ...
Faster Brain Stimulation for Depression Needs Dose, Spacing and Durability Proof, Not Just Speed
A new opinion article argues that accelerated transcranial magnetic stimulation for depression should be evaluated as a constrained optimization of ...
Blood Pressure Cuff Technique Shows Early Safety Promise for Severe Childhood Brain Condition
A commentary in Pediatric Research finds that remote ischemic postconditioning is safe and feasible in children with AESD, clearing the ...
Zero Events, False Comfort: Why Less Oxygen Before Extubation Is Not Yet Proven Safer
A new correspondence in Pediatric Research argues that a trial showing less lung collapse with 50 percent pre-extubation oxygen in ...
Old Drugs, New Tricks: How Repurposing Could Crack Cancer’s Resistance Problem
A new review in Molecular Cancer maps how approved drugs from outside oncology could be repurposed, under a strict mechanism-first ...
Why Head and Neck Cancer Rehab Trials Must Stratify for Lymphoedema
A new correspondence in Supportive Care in Cancer argues that head and neck cancer rehabilitation trials must stratify participants by ...
Human Milk Diets and Preterm Growth: What the JASMINE Trial Really Tested in Japanese NICUs
A new editorial defends the JASMINE trial's finding that exclusive human milk-based diets improved growth in Japanese very low birth ...
Analyzing Phase 1 Oncology Trial Expansion Cohorts
In a transformative exploration of oncology trials, researchers are recalibrating the boundaries of early-phase studies through the application of expansion ...
Tofogliflozin vs. Metformin: Impact on Diabetic Kidney Disease
In a significant advancement in the management of diabetic kidney disease (DKD), researchers have initiated the TRUTH-DKD trial, which aims ...
Reevaluating Proteinuria as a Key Endpoint in IgA Nephropathy
A groundbreaking study conducted by a team of researchers led by Maillard, El Karoui, and Mercer has unearthed critical insights ...
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