Cell Cycle Timing Shapes How Natural Killer Cells Fire Their Weapons
A combined CyTOF and computational modeling study shows that NKG2D signaling and degranulation in human NK cells depend on the ...
Tag: cell cycle
Hepatitis B Virus X Protein Mutation T118N Reshapes Cell Cycle and Apoptosis in Liver Cells
New research shows that the hepatitis B virus X protein T118N mutation, common in Indonesia, increases Cyclin E expression and ...
ORC1: The Replication Gatekeeper Linking Genome Stability to Cancer
A new review in the Journal of Translational Medicine consolidates how the replication-initiation protein ORC1 safeguards genome stability and why ...
Bats and Whales Age Differently: Genomes Reveal Two Separate Roads to Long Life
A new comparative genomic study finds that small long-lived mammals like bats rely on DNA repair and autophagy while large ...
Chaperonin Protein CCT2 Emerges as Key Driver of Aggressive Head and Neck Cancer and Cisplatin Resistance
New research shows that the chaperonin subunit CCT2 stabilizes the oncoprotein c-Myc to drive head and neck squamous cell carcinoma ...
Rice Study Shows CDC20 Governs the Metaphase-to-Anaphase Switch in Both Mitosis and Meiosis
A CRISPR mutant series in rice reveals that three redundant CDC20 proteins control the metaphase-to-anaphase transition in both mitosis and ...
FuChi: A New Chicken Biosensor Illuminates Cell Cycle Dynamics in Living Embryos
Researchers have generated FuChi, the first viable Fucci cell cycle reporter line in an avian species, revealing that S phase ...
Faulty Epigenetic Switch Disrupts Brain Cell Cycles and Drives White Matter Defects in Autism-Linked Disorders
New research shows that pathogenic variants in the chromatin regulator MSL2 disrupt oligodendrocyte precursor cell division and myelination through loss ...
Body Clock Gene BMAL1 Plummets in Childhood Leukemia, Study Finds
A new study reports that the circadian clock gene BMAL1 and the cell cycle checkpoint regulator WEE1 are significantly downregulated ...
Editors Retract Breast Cancer Study After Overlapping Migration and Invasion Images Surface
The editors of Cancer Cell International have retracted a 2015 breast cancer study on cyclin D3 after discovering overlapping migration ...
Cell cycle clock controls RNA methylation through a hidden ubiquitin code
A new Nature Chemical Biology study reveals that the ubiquitin ligase RLIM tags the m6A writer METTL14 with noncanonical K27-linked ...
Securin Gene PTTG1 Emerges as Engine of Gastric Cancer’s Stepwise March
Single-cell sequencing, organoids, and xenografts reveal that the securin-encoding gene PTTG1 reprograms the G2/M checkpoint to drive the stepwise progression ...
Mulberry Compounds Outdock a Clinical Cancer Drug in CDK1 Simulation Study
A computational study finds that mulberry phytochemicals mulberrofuran L and X bind the cancer-critical CDK1 protein more stably than the ...
Cellular Freight Protein YKT6 Emerges as a Driver of Lung Cancer Growth
A new study finds that the vesicle-trafficking SNARE protein YKT6 is overexpressed in lung cancer, where it drives proliferation and ...
Loss of a Single Protein Derails Brain Development and Drives Autism-Like Behavior in Mice
New research shows that the protein UBAP2L is essential for neural progenitor cell division, and that its loss in mice ...
Metarrestin’s Anti-Cancer Mechanism Mapped Through Network Pharmacology
A new network pharmacology study maps how the anti-metastatic drug metarrestin rewires cancer cell protein networks and identifies the cell-cycle ...
EPCR Essential for ECFC Growth and Angiogenesis
Human endothelial colony forming cells (ECFCs) have recently come under the spotlight in the realm of vascular biology, with researchers ...
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