Patient-derived cancer models expand dependency maps but expose new limits
Hundreds of patient-derived cancer models expanded dependency mapping and revealed vulnerabilities linked to mutations, cellular states and treatment history, while ...
Tag: cancer genomics
Review maps mechanisms, diagnosis and treatment of primary cardiac angiosarcoma
A 2026 review summarizes recurrent molecular alterations, immune suppression, multimodal imaging and current treatment strategies for primary cardiac angiosarcoma, a ...
Genome-wide analysis links tumor deletion patterns to alternative DNA repair
A whole-genome analysis of 2,157 tumors across 17 cancer types identified distinct deletion patterns associated with two backup DNA-repair pathways, ...
Single-cell map reveals lncRNA networks shaping cancer outcomes
A pan-cancer single-cell framework identifies 667 cell-specific long noncoding RNAs and thousands of functional pairs linked to tumor heterogeneity and ...
Three-Day Whole Genome Sequencing Transforms Childhood Cancer Diagnosis
A UK study shows rapid whole genome sequencing cuts pediatric cancer diagnosis time from six weeks to three days while ...
Whole-genome scan of 1,001 prostate cancers reveals hidden drivers and four risk oncotypes
A whole-genome analysis of 961 primary prostate tumours reveals recurrent driver alterations, enhancer hijacking at solute carrier genes, and four ...
New Tool HiFIseek Hunts Hidden Cancer Mutations in the Genome’s Dark Regulatory Regions
A new computational pipeline called HiFIseek systematically links damaging non-coding mutations to cancer genes, revealing that regulatory regions of drivers ...
Cell-Free DNA Reflects Tumor Transcription Factor Activity
In a groundbreaking study, Tamaki et al. have unveiled a novel method utilizing cell-free DNA (cfDNA) to explore the activities ...
Dog Genetics Provide Insights into Human Gastric Cancer
In a groundbreaking study published in the prestigious Proceedings of the National Academy of Sciences, researchers from Cornell University have ...
New Insights into FOXR2 Activation Across Brain Tumors Enhance Diagnostic Precision and Patient Care
In a groundbreaking development that challenges established conventions in neuro-oncology, researchers at St. Jude Children’s Research Hospital have unveiled compelling ...
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