Too Much Calcium Traps Muscle Stem Cells in Growth Mode, Blocking Repair
New research shows that chronic intracellular calcium overload keeps muscle progenitor cells proliferating through sustained NFATc1 signaling, impairing regeneration, and ...
Tag: Calcium signaling
Lipid Nanoparticles Trigger Pain Receptor TRPA1 and Reshape Calcium Signaling in Cells
New research shows that synthetic lipid nanoparticles trigger irregular calcium signals in cells partly through the pain-sensing ion channel TRPA1, ...
Injectable Piezoelectric Hydrogel That Strengthens Itself Rewires Stem Cell Genes to Rebuild Bone
A self-reinforcing injectable hydrogel converts body movement into electrical signals that trigger calcium-dependent histone acetylation and accelerate bone regeneration in ...
How Broken Mitochondria Send Cancer Cells Into Survival Mode
A new review details how disrupted mitochondrial homeostasis and activated retrograde signaling drive cancer progression and may open fresh therapeutic ...
Nerve Fibers Invade the Aging Lens, Revealing How Cataracts Take Hold
A single-cell atlas of 554 human cataract capsules reveals that nerve-like fibers invade the aging lens through an NRG1-ERBB3 signaling ...
Blood Pressure Drug Diltiazem Shows Promise Against Childhood Dementia
New research shows that the calcium channel blocker diltiazem suppresses parthanatos-related DNA damage and poly(ADP-ribose) accumulation in patient-derived cells from ...
Vitamin D Helps Plants Fight Salt Stress, Study Finds
New research shows that exogenous vitamin D2 and D3 protect Arabidopsis seedlings from salt stress by reducing sodium accumulation, restoring ...
Brain-Style NMDA Receptors Rewire Immune Cells Inside Tumors, Review Finds
A new review describes how NMDA glutamate receptors on myeloid cells drive calcium-dependent reprogramming toward immunosuppressive states, and how blocking ...
Lipid Signal 12-HHT Helps Cells Patch Membranes Torn by Bacterial Toxins
Researchers at Juntendo University have discovered that the lipid mediator 12-HHT and its receptor BLT2 form an emergency membrane-repair pathway ...
Misplaced Gap Junction Protein Drives Colorectal Cancer Spread—and Reveals a Drug Weakness
Researchers found that the gap junction protein Cx26 relocates to mitochondria in metastatic colorectal cancer, driving EMT and calcium signaling, ...
Inside the cilium: how dynein motors are tuned by a web of regulatory signals
A new review in Cellular and Molecular Life Sciences details how dynein motor proteins in the ciliary axoneme are regulated ...
Calcium Signals Reveal How Seeds Decide to Germinate in Salty Soil
Researchers at the Hebrew University of Jerusalem have identified a calcium-controlled signaling system involving CAMTA6, PP2C49, and HKT1;1 that helps ...
M6A Modification Boosts Osteosarcoma Progression via Ca2+ Signaling
Recent research has made significant strides in unveiling the molecular underpinnings of osteosarcoma, a challenging and aggressive bone malignancy predominantly ...
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