Loop CAR-T Cells Target Heterogeneous Leukemia Antigens
New loop-structured CAR-T cells targeting CD38 and CD123 show enhanced activity against heterogeneous acute myeloid leukemia in preclinical models.
Tag: bispecific antibodies
Narrative Review Examines Dual Cardiovascular Toxicities of Bispecific Antibody Ivonescimab
A narrative review evaluates the dual vascular and immune-mediated cardiotoxicity profile of the bispecific antibody ivonescimab and proposes a risk-stratified ...
Fever After CAR T-Cell Therapy: New Push for Early Detection of Toxicity
A new review in Blood Research outlines how early detection, risk prediction models, and phenotype-directed treatment are reshaping the management ...
Immunotherapy Safety Data May Not Apply to Borderline Resectable Lung Cancer
A narrative review argues that safety data from six phase 3 immunotherapy trials in resectable lung cancer may not transfer ...
mRNA-encoded antibodies show early clinical promise in cancer therapy
A Journal of Translational Medicine review outlines how mRNA-encoded antibodies, bispecific constructs, and transient CAR expression could overcome the manufacturing ...
Antibody–Drug Conjugates Reshape Solid Tumor Therapy Amid Safety and Target Challenges
A new review in Holistic Integrative Oncology charts the rapid rise of antibody–drug conjugates in solid tumors while detailing the ...
Cancer’s Master Switch: New Map Reveals How Tumors Outsmart Immunotherapy
A sweeping new review in Molecular Cancer maps the PD-1/PD-L1 axis from immune evasion mechanisms to next-generation therapeutics, offering a ...
Guided missiles of cancer medicine: how antibody-drug conjugates are rewriting targeted therapy
A comprehensive Molecular Cancer review explains how antibody-drug conjugates deliver lethal payloads to tumors, why resistance emerges, and which next-generation ...
mRNA-Delivered Bispecific Antibodies Show Promise Against Evolving SARS-CoV-2 Variants
Researchers have engineered mRNA-delivered bispecific antibodies derived from llama candidates that neutralize a broad range of SARS-CoV-2 variants and protected ...
Immune Checkpoint Blockers and Engineered Cells Reshape the Fight Against Oral Cavity Cancer
A new review in Molecular Biology Reports maps how checkpoint inhibitors, engineered cell therapies, and emerging immunotherapies are transforming treatment ...
Immune Cell Engagers Evolve From Simple Bridges to Smart Biomaterial Platforms
A new review charts how immune cell engagers, from bispecific antibodies and aptamers to surface-engineered cells and nanoparticles, are being ...
Antibody–Drug Conjugates Emerge as Immune Modulators, Not Just Targeted Chemotherapy
A new review argues that antibody–drug conjugates act as immune modulators through immunogenic cell death, Fc-mediated effector functions and tumour ...
New Wave of Targeted and Immune Therapies Reshapes Marginal Zone Lymphoma Care
A new review in Annals of Hematology details how molecular profiling and a growing arsenal of targeted and immune-based therapies ...
Bystander T Cells Boost the Antitumor Efficacy of Bispecific Antibodies
Researchers are continuing to make strides in the field of immunotherapy, particularly focusing on the treatment of relapsed or refractory ...
