Acne Drug Isotretinoin Calms Inflammation at Gene and Blood Levels, Study Finds
New research shows oral isotretinoin suppresses five key pro-inflammatory cytokines at both gene and protein levels in acne patients, with ...
Tag: biomarker
Crushed by Crowding: Tumor Pressure Triggers Cancer Cell Self-Destruction, Study Finds
New research shows that sustained mechanical confinement inside densely packed tumors activates necroptosis in migratory cancer cells, halting metastasis and ...
Brain Tumor Biomarker Survives Tough Test: MGMT Signal Holds After Batch Effect Scrutiny
St. Jude researchers show that the link between MGMT expression and survival in H3 G34-mutant diffuse hemispheric glioma withstands adjustment ...
Scientists Urge Caution Before Using MGMT to Guide Treatment of Rare Childhood Brain Cancer
A new correspondence in Acta Neuropathologica warns that technical artifacts in RNA sequencing data must be resolved before MGMT expression ...
Blood enzyme linked to jawbone destruction reveals surprise role for stress hormones in bone disease
A multicentre proteomics study finds that patients with medication-related osteonecrosis of the jaw have significantly reduced circulating dopamine β-hydroxylase, linking ...
Chemokine Gene Methylation Tied to Liver Inflammation in Chronic Hepatitis B
Researchers found that reduced methylation of the CXCL16 gene promoter in chronic hepatitis B patients tracks with elevated chemokine expression ...
Simple Blood Ratio Predicts Diabetes Risk Years Before Diagnosis, Study Finds
A decade-long Chinese cohort study found that people with the highest platelet-to-HDL cholesterol ratio had a 41 percent greater risk ...
Blood Lipid Patterns Could Predict Which Breast Cancers Respond to Chemotherapy
A new study finds that dynamic changes in blood lipid levels during chemotherapy can predict with high accuracy which luminal ...
Adropin: The Metabolic Hormone Rewiring the Map of Chronic Disease
A new review maps how the peptide hormone adropin, once seen as a simple metabolic signal, orchestrates vascular, neurological, fibrotic, ...
Cholesterol Plummets in Oral Cancer Patients, Huge Meta-Analysis Finds
A new meta-analysis of 25 studies finds that oral cancer patients show significantly lower total cholesterol, triglycerides, HDL, LDL, and ...
Damaged Mitochondrial DNA Emerges as a Central Driver of Pulmonary Arterial Hypertension
A new review argues that oxidized mitochondrial DNA acts as both a persistent inflammatory signal and a potential biomarker driving ...
Sticky Protein MUC5AC Emerges as Powerful Tissue Marker for Pancreatic Cancer and Precursors
A meta-analysis of 55 studies shows the mucus protein MUC5AC distinguishes pancreatic cancer and precancerous lesions from healthy and benign ...
Blood Test for Tumor DNA Predicts Survival After Cancer Treatment Before Surgery
A meta-analysis of 41 studies and 3,058 patients shows that detectable circulating tumor DNA after neoadjuvant therapy strongly predicts worse ...
Two Approved Companion Diagnostics Validate Pembrolizumab Eligibility Across dMMR/MSI-H Tumors
Bridging studies confirm that the Ventana MMR RxDx Panel and FoundationOne CDx reliably identify dMMR/MSI-H tumor patients likely to respond ...
High Ferritin Levels Flag Deadly Risk in Tuberculosis Patients with Low Blood Counts
A retrospective cohort study finds that pulmonary tuberculosis patients with bicytopenia or pancytopenia and serum ferritin above 500 micrograms per ...
Ribosome-Building Enzyme DIMT1 Emerges as a Pan-Cancer Biomarker and Gastric Cancer Drug Target
A comprehensive pan-cancer study identifies the ribosome biogenesis enzyme DIMT1 as a prognostic and immune-associated biomarker whose depletion suppresses gastric ...
A Single Blood Lipid Could Tell Two Deadly Liver Cancers Apart
Researchers have identified the lipid sphingomyelin (30:1; O2) as a blood-based biomarker that outperforms conventional tumor markers in distinguishing intrahepatic ...
Tiny Blood-Borne Molecule Shows Promise as an Early Warning Sign for Diabetes
A population-based nested case-control study finds that circulating miR-335-5p is elevated in diagnosed diabetes but lower before onset, improves two ...
Autistic Children With Sound Sensitivities Show Distinct Brain Signature to Speech Timing
A large study of Chinese children finds that autistic children with auditory atypicalities show an exaggerated brain response to changes ...
Lactate emerges as both warning sign and driver of kidney injury after heart surgery
A new iScience study combining machine learning on over 6,500 patient records with rat and cell experiments shows that lactate ...
