AI Platform Redesigns Enzymes to Run on Cheap Synthetic Cofactors
A new AI-guided design platform called HelixWings engineered two P450 enzymes to use the inexpensive biomimetic cofactor NMNH, boosting catalytic ...
Tag: biocatalysis
Engineered enzymes flip a molecular switch to control ester bond placement
Researchers engineered aldehyde dehydrogenases into oxidative ester synthases whose regioselectivity for primary or secondary alcohols is controlled by imidazole acting ...
Baker’s yeast turns benzaldehyde into a chiral building block in student lab
A laboratory study shows baker's yeast catalyzes the acyloin condensation of benzaldehyde to (R)-PAC, with quantitative proton NMR revealing that ...
Laccase review maps oxygen-driven routes to greener organic synthesis
A review of laccase catalysis shows how oxygen-driven enzymes can support greener oxidation, coupling, cyclization and polymerization reactions when enzyme, ...
Bacteria-Derived Enzyme Turns Lemongrass Compound Into Skin Shield Against Sun Damage
Researchers engineered an enzymatic route from citral to geranic acid with over 98 percent trans purity and showed the biosynthesized ...
Bacterial Enzyme Breakthrough Paves the Way for Greener Drugs and Food Ingredients
Researchers at ITQB NOVA have characterised the first bacterial galactose oxidase and engineered it into a biocatalyst up to 1800 ...
Common Plant Compound Supercharges Fungal Enzyme Factory in Surprising Trade-Off
Researchers at Inner Mongolia University found that adding p-coumaric acid to cultures of the fungus Funalia trogii boosts laccase production ...
Soil Bacterium Yields a Surprisingly Powerful Enzyme for Breaking Down PET Plastic Intermediates
A carboxylesterase from Bacillus halotolerans outperforms known enzymes at converting the PET breakdown products BHET and MHET into terephthalic acid, ...
Engineered E. coli strains keep fragile nitro compounds alive for green chemistry
Researchers have engineered E. coli strains carrying up to 15 nitroreductase gene deletions that retain and biosynthesize diverse nitroaromatic compounds, ...
Bacterial Enzyme KwwB Forges Unusual Peptide Cross-Links and Shrugs Off Leader Mutations
Researchers have shown that the P450 cyptide synthase KwwB can install a non-native Tyr-C3–Trp-N1 cross-link on engineered precursor peptides and ...
Microbe Team Turns CO2 Electrolysis Waste Into Valuable Chemicals
University of Delaware researchers have designed a two-step microbial process that converts formate, acetate and ethanol from electrocatalytic CO2 reduction ...
Heat-proof sugar enzyme gets a power boost through two tiny mutations
Crystal structures of an engineered hyperthermophilic sugar dehydrogenase reveal how two mutations relieve a steric barrier and boost calcium uptake ...
Green Solvent and Supercomputer Simulations Unlock a Stubborn Tea Enzyme
Researchers replaced toxic t-butanol with a menthol-octanoic acid deep eutectic solvent to purify tea membrane-bound polyphenol oxidase 17-fold, using molecular ...
Revolutionary Biodegradable Nylon Precursor Created via Artificial Photosynthesis
Osaka Metropolitan University scientists have made significant strides in the field of sustainable materials, particularly in the synthesis of biodegradable ...
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