JPT1 Protein Suppresses Mitophagy and Signals Poor Survival in Head and Neck Cancer
Elevated JPT1 expression in head and neck squamous cell carcinoma correlates with poorer overall patient survival and impairs cellular mitophagy ...
Tag: bafilomycin A1
Platelet Lysates Protect Neurons and Restore Autophagic Flux in Parkinson’s Disease Models
Platelet lysates alleviate neurotoxin-induced injury and restore impaired autophagic flux in cell and mouse models of Parkinson's disease via ROS/Akt ...
Optogenetic Tool ASAP Shuts Down Cellular Autophagy Within Five Minutes
Researchers have engineered a light-activated molecular tool termed ASAP that acutely and reversibly inhibits cellular autophagy within five minutes, revealing ...
V-ATPase Inhibition Lowers Extracellular ATP and Glutamate, Delaying Frog Neural Tube Closure
Pharmacological inhibition of V-ATPase with bafilomycin A1 reduces extracellular accumulation of ATP and glutamate and concentration-dependently delays neural tube closure ...
PLK2 Linked to Autophagic Dysfunction and Tubular Injury in Diabetic Kidney Disease
Researchers identified polo-like kinase 2 as an independent correlate of tubulointerstitial injury and autophagic dysfunction in diabetic kidney disease through ...
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