Review Highlights How Ferroptosis Regulates Immune Cell Function Across Diverse Diseases
A comprehensive review details how ferroptosis regulates immune cell survival and function across diverse inflammatory, infectious, and autoimmune diseases.
Tag: adaptive immunity
Peptide-Binding Motifs Define Functional Architecture of Human Leukocyte Antigens
Researchers mapped the functional architecture of human leukocyte antigens across 155 class I and 93 class II allotypes into 40 ...
Higher HLA Epitope Mismatch Links to Innate Immune Skewing in Liver Transplants
A translational study reveals that higher predicted donor-recipient HLA epitope mismatch associates with distinct innate immune cell configurations in clinically ...
Review Outlines RNA Sequencing Advances in TCR and BCR Repertoire Profiling
A methodological review details how high-throughput sequencing and specialized bioinformatics pipelines extract T-cell and B-cell receptor repertoires to track immune ...
Walnut Diet Alters Human Immune Gene Activity Without Changing Cell Numbers
A clinical study reveals that three weeks of daily walnut consumption alters gene expression in human peripheral blood mononuclear cells ...
Exploratory Study Analyzes T-Cell Receptor Repertoires in Drug-Resistant Tuberculosis
An exploratory study using adaptive immune receptor repertoire sequencing identified preliminary differences in peripheral blood TCRβ CDR3 repertoire characteristics between ...
Tinostamustine Plus Nivolumab Linked to Immune Responses in Advanced Melanoma
A longitudinal immune monitoring study showed that combining tinostamustine with nivolumab was linked to preserved adaptive immune competence and antigen-specific ...
Kidney transplant recipients hold on to RSV immunity despite immunosuppression
A Dutch study finds that kidney transplant recipients maintain RSV-specific antibodies and memory T cells comparable to healthy controls despite ...
Fetal Immune System Traced Across Gestation in New Review
A review in Frontiers in Pediatrics summarizes how the fetal adaptive and innate immune systems develop across gestation and how ...
RAG Transposon Co-Option Reshaped the Jawed Vertebrate Immune System
A new review proposes that the RAG transposon was co-opted in two stages to help create the V(D)J recombination system ...
Damaged Mitochondria and Runaway Glycolysis Reshape Immune Responses, Review Finds
A new review proposes that compensatory upregulation of fermentative glycolysis following mitochondrial dysfunction integrates and modulates the immune responses triggered ...
Fish Guts Reveal Ancient Origins of Antibody Factory Structures
Researchers have discovered inducible germinal center-like structures in the gut of common carp, showing that sophisticated mucosal antibody responses evolved ...
Gamma Delta T Cells Blur the Line Between Innate and Adaptive Immunity
New research in Nature shows that gamma delta T cells rely on their adaptive T cell receptors in real time ...
Efficacy Longevity of 2024-2025 COVID-19 Vaccines Against Emerging JN.1 Subvariants
The ongoing global battle against COVID-19 has entered a new chapter with the introduction of the updated 2024-2025 vaccines, which ...
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