• HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
Monday, August 25, 2025
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Health

Study of acute myeloid leukemia patients shows protein inhibitor drug safe and effective with durable remissions

Bioengineer by Bioengineer
June 2, 2018
in Health
Reading Time: 2 mins read
0
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram
IMAGE

Credit: MD Anderson Cancer Center

HOUSTON ? Ivosidenib, an experimental drug that inhibits a protein often mutated in several cancers has been shown to be safe, resulting in durable remissions, in a study of acute myeloid leukemia (AML) with relapsed or refractory disease.

The multi-center Phase I trial, led by researchers at The University of Texas MD Anderson Cancer Center, was designed to determine ivosidenib's safety and efficacy in treatment of patients with a form of AML in which the enzyme isocitrate dehydrogenase 1 (IDH1) is mutated. IDH1 mutations occur in 6 to 10 percent of AML patients. Findings are published today in the June 2 online issue of the New England Journal of Medicine and presented at the American Society of Clinical Oncology Annual Meeting in Chicago.

This first study of ivosidenib in humans, which enrolled patients between March 2014 and May 2017, administered a daily dose of the targeted IDH1 inhibitor to 258 patients.

"Ivosidenib, when administered orally as a single agent, was associated with acceptable side effects and induced durable and deep remissions," said Courtney DiNardo, M.D., assistant professor of Leukemia at MD Anderson. "In the trial's primary analysis cohort of 125 patients with IDH1-mutated relapsed or refractory AML treated at the recommended 500 mg daily dose, ivosidenib led to an overall response rate of 41.6 percent and a complete remission rate of 21.6 percent."

The study also reported that 30.4 percent of those 125 patients were in complete remission but with blood counts not fully restored. The overall survival rate was 50.1 percent at 18 months, as compared to historical overall survival of less than five months for patients with relapsed AML and two prior therapies.

"Among patients achieving complete remission or complete remission with partial hematologic recovery, 21 percent had no residual detectable IDH1 mutations," said DiNardo. "While the significance and prognostic impact of ongoing detection of IDH1 mutations remains unknown, further evaluation of changes in IDH1 mutations over time with ivosidenib therapy will be important avenues of research."

###

Hagop Kantarjian, M.D., chair of Leukemia at MD Anderson, also participated in the study. Other study institutions included Memorial Sloan-Kettering Cancer Center, New York; Institute Gustave Roussy, Villejuif, France; Weill Cornell Medical College, New York; Northwestern University, Chicago; Ohio State University Wexner Medical Center, Columbus; University of Miami; The University of Texas Southwestern Medical Center, Dallas; University of California, San Francisco; University of Colorado School of Medicine, Aurora; Sarah Cannon Research Institute, Nashville, Tenn.; Massachusetts General Hospital Cancer Center, Boston; Centre Hospitalier Universitaire, Bordeaux, France; University of Alabama at Birmingham; Johns Hopkins University, Baltimore; City of Hope Medical Center, Duarte, Calif.; Washington University School of Medicine, St. Louis; Mayo Clinic, Jacksonville, Fla.; University of Oregon Health & Science University Knight Cancer Institute, Portland, Ore.; Medical University of South Carolina, Charleston; Emory University School of Medicine, Atlanta; Mayo Clinic, Phoenix; Cleveland Clinic, Cleveland; Agios Pharmaceuticals, Inc., Cambridge, Mass.; and Dana-Farber Cancer Institute, Boston.

The study was funded by Agios Pharmaceuticals, Inc., Cambridge, Mass. DiNardo serves in an advisory role for Agios and Celgene, and Kantarjian is an advisor for Agios.

Media Contact

Ron Gilmore
[email protected]
575-915-5790
@mdandersonnews

http://www.mdanderson.org

Share12Tweet7Share2ShareShareShare1

Related Posts

Nurses’ Views on Online Learning: Effects on Performance

Nurses’ Views on Online Learning: Effects on Performance

August 25, 2025
blank

Carotid Calcifications and Pulp Stones: Diabetes Warning?

August 25, 2025

Link Between Type 2 Diabetes and Heart Failure Uncovered

August 24, 2025

Nature’s Remedies: Green Chemistry for Prostate Health

August 24, 2025
Please login to join discussion

POPULAR NEWS

  • blank

    Molecules in Focus: Capturing the Timeless Dance of Particles

    141 shares
    Share 56 Tweet 35
  • Breakthrough in Computer Hardware Advances Solves Complex Optimization Challenges

    134 shares
    Share 54 Tweet 34
  • New Drug Formulation Transforms Intravenous Treatments into Rapid Injections

    115 shares
    Share 46 Tweet 29
  • Neuropsychiatric Risks Linked to COVID-19 Revealed

    81 shares
    Share 32 Tweet 20

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Recent News

Unveiling Archaeoniscus brodiei: Early Cretaceous Isopod Insights

Assessing Runting Causes and Impacts in Poultry Hatcheries

Post-Fire Growth Insights of Cyathea Mexiae in Brazil

  • Contact Us

Bioengineer.org © Copyright 2023 All Rights Reserved.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

Bioengineer.org © Copyright 2023 All Rights Reserved.