• HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
Friday, August 1, 2025
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Science

Stem cell scientists clear another hurdle in creating transplant arteries

Bioengineer by Bioengineer
May 9, 2019
in Science
Reading Time: 3 mins read
0
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

IMAGE

Credit: Thomson Lab, Morgridge Institute for Research

MADISON — Cardiovascular disease is a major cause of death worldwide, and treating it isn’t easy. The disease wreaks havoc on patients’ blood vessels and can require complex bypass surgery.

Scientists at the Morgridge Institute for Research are working toward a dream of creating artery banks — similar to blood banks common today — with readily-available material to replace diseased arteries during surgery.

The latest work in the lab of Morgridge regenerative biologist James Thomson puts the science one step closer to that goal.

In a paper published online in Stem Cell Reports on May 9, 2019, the Thomson Lab highlights a better way to grow smooth muscle cells, one of the two cellular building blocks of arteries, from pluripotent stem cells. The work also identifies a potential drug for reducing post-surgical risks in patients who undergo bypass surgery.

“We decided to focus on blood vessels because cardiovascular disease is a major cause of death worldwide,” Thomson says. “In the U.S. for example, heart disease and stroke are the No. 1 and No. 3 killers, respectively. And this work also has implications beyond making vessels for transplantation; it’s sort of a stepping stone to more advanced tissue engineering.”

Producing arteries in the lab requires two essential cell types: endothelial cells and smooth muscle cells. In 2017, the lab demonstrated methods to generate and characterize endothelial cells, while the new research focuses on the smooth muscle cells.

Jue Zhang, lead author and a Morgridge associate scientist, says widely used growth factors for producing smooth muscle cells from stem cells can also cause intimal hyperplasia, one of the most common reasons a bypass graft fails.

In intimal hyperplasia, a portion of the arterial wall thickens–due to proliferation and migration of smooth muscle cells–and causes a narrowing of the blood vessel.

“We wanted to have a protocol that can reduce the risk of intimal hyperplasia,” Zhang says. “It’s a common problem in smooth muscle cell differentiation, and if you want to make a useful artery, you don’t want that risk.”

Healthy smooth muscle cells need the ability to contract, which helps them distribute blood throughout the body and regulate blood pressure. Using a high throughput screen, the team identified a small molecule, known as RepSox, that had the best potential to produce cells with contractile properties.

RepSox was identified out of a screen of 4,804 small molecules. In contrast to current widely used growth factors, RepSox inhibits intimal hyperplasia. It’s more stable than these growth factors and is also a cheaper alternative.

The characteristics that make RepSox good for differentiating smooth muscle cells also make it a desirable drug candidate to reduce risk of post-surgery complications, like intimal hyperplasia. Thus, this stem cell based high throughput screen can be used as a novel strategy for identifying drugs to restrict narrowing of blood vessels.

“Even after you have a bypass surgery, you can have some problems with your artery, like restenosis (narrowing arteries) due to intimal hyperplasia,” Zhang says. “Currently there are only two FDA-approved drugs on the market [to address these problems], and they’re not cell-type specific, meaning they have side effects. We found that RepSox inhibits intimal hyperplasia and has fewer side effects.”

RepSox is cell-type specific, so it inhibits smooth muscle cells and prevents the development of intimal hyperplasia without affecting neighboring cell types like endothelial cells.

While this finding brings scientists closer to improving treatments for cardiovascular disease, Zhang says there’s still another challenge to address: cell maturity.

“Basically this cell type is better than previous efforts, but it’s still not mature yet,” Zhang says. “We need to induce these cells to become more mature, to be more similar to our native artery, to make it more functional.”

###

Media Contact
Jue Zhang
[email protected]

Related Journal Article

http://dx.doi.org/10.1016/j.stemcr.2019.04.013

Tags: BiologyBiomedical/Environmental/Chemical EngineeringCardiologyCell BiologyStroke
Share13Tweet8Share2ShareShareShare2

Related Posts

Five or more hours of smartphone usage per day may increase obesity

July 25, 2019
IMAGE

NASA’s terra satellite finds tropical storm 07W’s strength on the side

July 25, 2019

NASA finds one burst of energy in weakening Depression Dalila

July 25, 2019

Researcher’s innovative flood mapping helps water and emergency management officials

July 25, 2019
Please login to join discussion

POPULAR NEWS

  • Blind to the Burn

    Overlooked Dangers: Debunking Common Myths About Skin Cancer Risk in the U.S.

    60 shares
    Share 24 Tweet 15
  • Dr. Miriam Merad Honored with French Knighthood for Groundbreaking Contributions to Science and Medicine

    46 shares
    Share 18 Tweet 12
  • Study Reveals Beta-HPV Directly Causes Skin Cancer in Immunocompromised Individuals

    37 shares
    Share 15 Tweet 9
  • Engineered Cellular Communication Enhances CAR-T Therapy Effectiveness Against Glioblastoma

    35 shares
    Share 14 Tweet 9

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Recent News

Host-Pathogen Fumarate Control Fuels Staph Pneumonia

Decelerated Protein Translation Accelerates Brain Aging in Killifish

Neuropsychiatric Risks Linked to COVID-19 Revealed

  • Contact Us

Bioengineer.org © Copyright 2023 All Rights Reserved.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

Bioengineer.org © Copyright 2023 All Rights Reserved.