• HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
Wednesday, September 24, 2025
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News

Researchers chart global genetic interaction networks in human cancer cells

Bioengineer by Bioengineer
February 2, 2017
in Science News
Reading Time: 4 mins read
0
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram
IMAGE

Credit: Sigrid Knemeyer

Cambridge, MA, February 2, 2017– Cancer is a heterogeneous disease, with myriad distinct subtypes that differ in their genetic roots. As a result, cancers rely on varied pathways for survival–and respond differently to anticancer agents. The challenge for researchers is to precisely define those diverse pathways and pinpoint vulnerabilities that may serve as drug targets for new anti-cancer treatments.

Investigators at Whitehead Institute and the Broad Institute have taken an important step in tackling that challenge: They have succeeded in identifying the set of essential genes–those required for cellular proliferation and survival–in each of 14 human acute myeloid leukemia (AML) cell lines that had previously been characterized by genome sequencing. By combining their "gene essentiality map" with the existing genomic information, their study revealed liabilities in genetically defined subset of cancers that could be exploited for new therapies.

The report on their work, appearing in the online edition of Cell, is entitled, Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras.

A major aspect of the study focuses on the genes and protein pathways connected to the Ras oncogene, the most commonly mutated oncogene in human cancers which plays a role in AML as well as many other cancers. "For the most part, the mutant Ras protein itself has been considered to be 'undruggable'," explain Tim Wang, the paper's first author and an MIT graduate student researcher at Whitehead Institute and the Broad Institute. "An alternative approach has been to find other genes that Ras-mutant cancers rely on with the hope that one of them may be druggable. Unfortunately, such 'Ras-synthetic-lethal' genes have been difficult to identify,." notes Wang.

Using CRISPR-based gene editing technique, the researchers could gauge the impact of individually knocking out each of the 18,000 protein-coding genes in the human genome. "This process rapidly enabled us to identify the short list of genes that were selectively required in only the Ras-mutant cells," explained David Sabatini, a senior author on the paper, as well as a Member of the Whitehead Institute, Pprofessor of Biology at MIT, and an investigator of the Howard Hughes Medical Institute. "We think this general approach can be applied to find vulnerabilities in many more cancer types."

In addition to defining the Ras-specific gene essentiality network, the data generated from this study also allowed the researchers to decipher the molecule function of previously unstudied genes. They started by focusing in on genes that were essential in some of the cell lines but dispensable for others. For each of these genes, the researcher sifted through their data to find others that showed a matching pattern of essentiality with the idea that all of them had similar functions. Indeed, this 'guilt-by-association' analysis revealed gene groups that were already known to act together and uncovered novel associations between genes that were not known to be related or had been previously unstudied.

"What's particularly exciting about this work is that we have just begun to scratch the surface with our method," Wang concludes. "By applying it broadly, we could reveal a huge amount of information about the functional organization of human genes and their roles in many diseases."

###

Tim Wang is a doctoral student at MIT, co-advised by Sabatini and Lander, and conducts research in the Sabatini lab at Whitehead Institute.

David Sabatini is a Member of Whitehead Institute, where he conducts his research, and a Pprofessor of Biology at MIT.

Eric Lander is president and founding director of the Broad Institute of MIT and Harvard, a Pprofessor of Biology at MIT, and a Professor of Systems Biology at Harvard Medical School

Full Citation:

Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras

Cell (online publication), Feb. 2, 2017

Authors:

Tim Wang,1,2,3,4,5 Haiyan Yu,2 Nicholas W. Hughes,2,3,4,5 Bingxu Liu,2,3,4,5 Arek Kendirli,2,6 Klara Klein,2,6 Walter W. Chen,1,2,3,4,5 Eric S. Lander,1,2,7,* and David M. Sabatini1,2,3,4,5,8,**

Affiliations:

1Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA

2Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA

3Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA

4David H. Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA

5Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA

6German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany

7Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA

8Lead contact

*Correspondence: [email protected]

**Correspondence: [email protected]

Funding and Potential Conflicts:

This work was supported by the NIH (CA103866 to D.M.S.; F31 CA189437 to T.W), the National Human Genome Research Institute (2U54HG003067-10) (to E.S.L.), and the MIT Whitaker Health Sciences Fund (to T.W.). D.M.S. is an investigator of the Howard Hughes Medical Institute.

T.W., D.M.S., and E.S.L. are inventors on a patent for functional genomics using CRISPR-Cas (US 15/141,348).

T.W. and D.M.S are founders, and D.M.S. is an advisor of KSQ Therapeutics.

Whitehead Institute is a world-renowned non-profit research institution dedicated to improving human health through basic biomedical research. Wholly independent in its governance, finances, and research programs, Whitehead shares a close affiliation with Massachusetts Institute of Technology through its faculty, who hold joint MIT appointments.

Media Contact

Merrill Meadow
[email protected]
339-223-7307
@WhiteheadInst

http://www.wi.mit.edu/index.html

############

Story Source: Materials provided by Scienmag

Share12Tweet8Share2ShareShareShare2

Related Posts

AI Enhances Endocytoscopy for Colorectal Lesion Detection

September 24, 2025

Narcissism, FOMO, and Social Media Addiction in College

September 24, 2025

Deep Learning Detects Newborn Pulmonary Hypertension Automatically

September 24, 2025

Teddy Bears as Conservation Tools: Why They Need a Fresh New Look

September 24, 2025
Please login to join discussion

POPULAR NEWS

  • Physicists Develop Visible Time Crystal for the First Time

    Physicists Develop Visible Time Crystal for the First Time

    70 shares
    Share 28 Tweet 18
  • Tailored Gene-Editing Technology Emerges as a Promising Treatment for Fatal Pediatric Diseases

    50 shares
    Share 20 Tweet 13
  • New Study Reveals the Science Behind Exercise and Weight Loss

    50 shares
    Share 20 Tweet 13
  • Scientists Achieve Ambient-Temperature Light-Induced Heterolytic Hydrogen Dissociation

    49 shares
    Share 20 Tweet 12

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Recent News

AI Enhances Endocytoscopy for Colorectal Lesion Detection

Narcissism, FOMO, and Social Media Addiction in College

Deep Learning Detects Newborn Pulmonary Hypertension Automatically

  • Contact Us

Bioengineer.org © Copyright 2023 All Rights Reserved.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

Bioengineer.org © Copyright 2023 All Rights Reserved.