Rensselaer researcher helps scientists make sense of vast amounts of molecular data

Thanks to technological advances, scientists have access to vast amounts of data, but in order to put it to work and draw conclusions, they need to be able to process it.

In research recently published in Genome Biology, Rensselaer Polytechnic Institute’s Boleslaw Szymanski, Ph.D., Claire and Roland Schmitt Distinguished Professor of Computer Science and director of the Network Science and Technology Center, and team have found a method that effectively organizes and groups the data for a variety of applications. The process is referred to as clustering in machine learning.

The clustering method they devised, called SpeakEasy2: Champagne, was tested alongside other algorithms to analyze its effectiveness in bulk gene expression, single-cell data, protein interaction networks, and large-scale human networks data. Bulk gene expression tends to be tissue and disease specific with implications on function and phenotype, or how a genotype interacts with the environment. Single cell data is grouped according to a cell’s distinctions. Protein binding is a core mechanism for signal propagation in cells, and identifying proteins that assemble into complexes is useful for defining functions within a cell.

The team’s testing of SpeakEasy2: Champagne alongside other methods revealed that no single method is perfect for all situations, and the performance can vary. However, SpeakEasy2 performed well across different types of data, suggesting that it’s an effective way to organize molecular information.

“We tested to determine if the methods worked well even if the data included a lot of irrelevant information and also new, unseen data,” said Szymanski. “We wanted to measure their reliability and performance in a number of ways, so we tested across a wide range of networks. SpeakEasy2: Champagne proved to have consistent and acceptable performance across diverse applications and metrics.”

“Optimizing machine learning methods to effectively integrate large amounts of noisy data is critical to advancing science across many research fields,” said Curt Breneman, Ph.D., dean of Rensselaer’s School of Science. “Dr. Szymanski’s work will allow new insights into cell function and gene expression and may illuminate new potential drug targets and their inhibitors to treat disease.”­­

This work was done in collaboration with Chris Gaiteri, Ph.D., of Rush University Medical Center and his team, and it is a result of a decade-long collaboration. Eight years ago, they collectively developed a novel clustering algorithm named SpeakEasy that, in light of vast new sources of biomedical data thanks to advances in computer science technologies, required more intelligent and faster software that will work for more diverse and greater amounts of biomedical data.

Gaiteri’s team includes David R. Connell; Faraz A. Sultan, M.D.; Artemis Latrou, Ph.D.; Bernard Ng, Ph.D.; Ada Zhang; and Shinya Tasaki, Ph.D.; all of whom contributed to the findings.

About Rensselaer Polytechnic Institute:

Founded in 1824, Rensselaer Polytechnic Institute is America’s first technological research university. Rensselaer encompasses five schools, over 30 research centers, more than 140 academic programs including 25 new programs, and a dynamic community made up of over 6,800 students and 110,000 living alumni. Rensselaer faculty and alumni include upwards of 155 National Academy members, six members of the National Inventors Hall of Fame, six National Medal of Technology winners, six National Medal of Science winners, and a Nobel Prize winner in Physics. With nearly 200 years of experience advancing scientific and technological knowledge, Rensselaer remains focused on addressing global challenges with a spirit of ingenuity and collaboration. To learn more, please visit www.rpi.edu.

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