• HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
Monday, September 1, 2025
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Biology

Pushing frontiers through upcycling: eggshell waste for bone graft material

Bioengineer by Bioengineer
April 24, 2023
in Biology
Reading Time: 3 mins read
0
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

Autologous and allogeneic bone grafts are considered the gold standard when it comes to reconstructing bones, largely due to their bioactive compounds and osteoblastic cells that can generate new bone effectively. However, limited supply, donor-site complications, and risk of disease transmission have deterred its widespread use.

FLOWCHART OF THIS RESEARCH: HOW TO CONVERT EGGSHELL WASTE INTO BIOACTIVE MATERIALS FOR BONE REGENERATION

Credit: QIANLI MA

Autologous and allogeneic bone grafts are considered the gold standard when it comes to reconstructing bones, largely due to their bioactive compounds and osteoblastic cells that can generate new bone effectively. However, limited supply, donor-site complications, and risk of disease transmission have deterred its widespread use.

In contrast, xenograft materials represent a feasible alternative because they are safe to use and come in abundance; even though they stem from mammalian tissue which is costly, poses environmental risks and ethical issues especially in underprivileged regions. Nonetheless, xenograft materials do have their limitations. Most commercialized xenograft materials are prepared from mammalian tissue with heavy bio-cost, environmental pollution and potential ethical issues, especially in underdeveloped areas.

Therefore, a top priority of bone graft materials development is to obtain safe, modifiable, and environmentally friendly synthetic biomaterials capable of replacing natural graft materials—the exact motivation that spurred a new discovery by an international team of researchers.

In the study, the team developed a dissolution-precipitation method to convert eggshells into endotoxin-free and immunocompatible amorphous calcium phosphate (ACP) particles. “Eggshells is an ideal raw material to synthesize bone graft materials as it contains plenty of calcium and phosphorous components,” said first author of the study, Dr Qianli Ma Qianli Ma the Department of Biomaterials at the University of Oslo (UiO). “In addition, some trace elements associated with bone regeneration, such as magnesium and strontium, are also found in eggshell.”

Further, the team established a novel 3D spheroid model for studying the osteogenic activity of eggshell ACP in vitro. In the model, ACP materials were observed to interact with osteoblasts more realistically, and were safe, cell-friendly and effective in promoting bone regeneration.

“This technique promises to create an unlimited supply of bioactive and sustainable bone graft materials while reducing the environmental pollution,” said senior and corresponding author Professor Håvard Jostein Haugen, who is from the same department at UiO. “The osteoblastic spheroids constructed in the study provided a more practical biomaterial research model, reflecting the three-dimensional interactions between cells and biomaterials.”

The researchers hope their latest findings, published in the KeAi journal Smart Materials in Medicine, would inspire further work on converting ordinary food waste into high value-added biomaterials. Meanwhile, the team is working towards an ideal in vitro model that can replace in vivo research in animal models.  

###

Contact the corresponding author: Håvard Jostein Haugen, Department of Biomaterials, Institute of Clinical Dentistry, University of Oslo, Norway. [email protected]

The publisher KeAi was established by Elsevier and China Science Publishing & Media Ltd to unfold quality research globally. In 2013, our focus shifted to open access publishing. We now proudly publish more than 100 world-class, open access, English language journals, spanning all scientific disciplines. Many of these are titles we publish in partnership with prestigious societies and academic institutions, such as the National Natural Science Foundation of China (NSFC).

 



Journal

Smart Materials in Medicine

DOI

10.1016/j.smaim.2023.04.001

Method of Research

Experimental study

Subject of Research

Cells

Article Title

Eggshell-derived amorphous calcium phosphate: Synthesis, characterization and bio-functions as bone graft materials in novel 3D osteoblastic spheroids model

COI Statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Share12Tweet8Share2ShareShareShare2

Related Posts

Unraveling Odorant Proteins in Kissing Bugs

September 1, 2025

Drumming in Mongolian Gerbils: Context or Arousal?

September 1, 2025

Seasonal Brain Shrinkage in Shrews Caused by Water Loss, Not Cell Death

September 1, 2025

Lower IGF1 Levels in Preeclampsia Affect Trophoblasts

September 1, 2025

POPULAR NEWS

  • blank

    Breakthrough in Computer Hardware Advances Solves Complex Optimization Challenges

    153 shares
    Share 61 Tweet 38
  • Molecules in Focus: Capturing the Timeless Dance of Particles

    143 shares
    Share 57 Tweet 36
  • New Drug Formulation Transforms Intravenous Treatments into Rapid Injections

    117 shares
    Share 47 Tweet 29
  • Do people and monkeys see colors the same way?

    112 shares
    Share 45 Tweet 28

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Recent News

Tailored Risk Messages Show No Impact on Increasing Colorectal Cancer Screening Rates

New Predictive Model for Postpartum Hemorrhage in Cesarean Cases

Novel ADC Targets Fucosyl-GM1 in Lung Cancer

  • Contact Us

Bioengineer.org © Copyright 2023 All Rights Reserved.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

Bioengineer.org © Copyright 2023 All Rights Reserved.