• HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
Friday, October 31, 2025
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News

Preclinical studies involving resistance to antiangiogenic therapies

Bioengineer by Bioengineer
November 18, 2016
in Science News
Reading Time: 2 mins read
0
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram
IMAGE

Credit: Dr. Michalis Mastri et al, Bentham Science Publishers

New blood vessel growth, or angiogenesis, is critical for cancer to grow and spread throughout the body. Drugs that target vascular endothelial growth factor (VEGF) — a key driver of angiogenesis — are now approved for the treatment of several metastatic cancers. However, not all patients respond and many more eventually become resistant after initial treatment benefits.

While researchers have sought to identify possible mechanisms to explain drug resistance the methods to study have proven complex. Preclinical studies seeking to identify reasons for antiangiogenic treatment failure have relied on animal models of cancer because the complex interaction between the tumor and the "normal" blood vessels that the treatment targets is difficult to reproduce in a petri dish. But the use of animal models can also increase the varience in results.

In a review published in the journal Current Drug Targets, researchers at Roswell Park Cancer Institute in Buffalo, New York, examined this variability and found that the many mechanisms of resistance identified in laboratory models are based on inconsistent definitions of treatment failure. "Most studies involve only a few drugs and animal models that do not fully recapitulate clinically relevant metastatic disease," said Dr. John Ebos, Assistant Professor at the Departments of Cancer Genetics and Medicine at Roswell Park. "Many excellent studies have been performed; however, it is difficult to determine which are most applicable to patients."

The literature considered in this new review highlights the challenges of studying resistance to inhibitors of tumor angiogenesis in preclinical models and the need to improve methodology to help qualify and quantify treatment failure to predict alternative strategies that will be of greatest benefit to patients.

###

For more information about the article, please visit http://benthamscience.com/journals/current-drug-targets/volume/17/issue/15/page/1747/

Reference: Mastri, M.; et al (2016). The Challenges of Modeling Drug Resistance to Antiangiogenic Therapy., DOI: 10.2174/1389450117666151209123544

Media Contact

Faizan ul Haq
[email protected]
@BenthamScienceP

http://benthamscience.com/

############

Story Source: Materials provided by Scienmag

Share12Tweet8Share2ShareShareShare2

Related Posts

blank

Microwave Extraction of Starch from Litchi Kernels

October 31, 2025
AI Awareness and Adoption in Greater Kumasi Residents

AI Awareness and Adoption in Greater Kumasi Residents

October 31, 2025

Myeloid Cell Signaling Identified as Key Driver of Immunotherapy Resistance in Kidney Cancer

October 31, 2025

University of Minnesota Researchers Secure $4M Grant for Pioneering Bipolar Disorder Study

October 31, 2025
Please login to join discussion

POPULAR NEWS

  • Sperm MicroRNAs: Crucial Mediators of Paternal Exercise Capacity Transmission

    1294 shares
    Share 517 Tweet 323
  • Stinkbug Leg Organ Hosts Symbiotic Fungi That Protect Eggs from Parasitic Wasps

    312 shares
    Share 125 Tweet 78
  • ESMO 2025: mRNA COVID Vaccines Enhance Efficacy of Cancer Immunotherapy

    202 shares
    Share 81 Tweet 51
  • New Study Suggests ALS and MS May Stem from Common Environmental Factor

    136 shares
    Share 54 Tweet 34

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Recent News

Microwave Extraction of Starch from Litchi Kernels

AI Awareness and Adoption in Greater Kumasi Residents

Myeloid Cell Signaling Identified as Key Driver of Immunotherapy Resistance in Kidney Cancer

Subscribe to Blog via Email

Enter your email address to subscribe to this blog and receive notifications of new posts by email.

Join 67 other subscribers
  • Contact Us

Bioengineer.org © Copyright 2023 All Rights Reserved.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

Bioengineer.org © Copyright 2023 All Rights Reserved.