It looks like your input was cut off mid-sentence. From what you’ve provided, the passage discusses the challenges in resolving associations between the HLA locus and immune-mediated complex traits, due to factors like allelic diversity, population heterogeneity, and the lack of well-estimated antigens.
Here’s a brief summary of the passage so far:
The HLA locus is tightly linked to immune-related traits, but understanding the specific associations is difficult.
The Epstein-Barr Virus (EBV) proteome provides a set of candidate antigens that interact with these HLA alleles.
Because these alleles variably present EBV antigens, this affects the presence of EBV DNAemia (presence of EBV DNA in blood).
The researchers assembled four-digit HLA allele data from donors of Non-Finnish European (NFE) or European (EUR) ancestry from UK Biobank (UKB) and All of Us (AOU) cohorts.
They performed multivariate regression to find associations between HLA alleles and EBV DNAemia.
They identified 42 associated HLA alleles in total (18 class I and 24 class II alleles) with a nominal P-value threshold (not fully detailed due to cutoff).
If you provide the rest of the text or your specific questions about this, I could assist further! Would you like me to help interpret this study further, summarize more, or analyze particular parts?
Tags: All of Us research programcandidate antigens in immunologyDNAemia and immune responseEBV antigens and HLA interactionEpstein-Barr Virus DNA persistenceHLA alleles association studyHLA locus and immune traitsimmune-mediated complex traitsmultivariate regression analysis in geneticsNon-Finnish European ancestry and EBVpopulation genetics of EBVUK Biobank genetic research
