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Home NEWS Science News Health

Patients with ALS are not only troubled by muscle weakness and respiratory dysfunction

Bioengineer by Bioengineer
August 22, 2022
in Health
Reading Time: 2 mins read
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Percentage of patients with each non-motor symptom who reported a decrease in quality of life (QoL)
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Non-motor symptoms such as pain, fatigue, and sleep disorders, are observed in patients with ALS and reduce their QoL. Many of the non-motor symptoms are poorly defined with unexplained mechanisms, are underdiagnosed, and remain unreported during clinical consultation. Although the non-motor symptoms of ALS were partially known, there has been so far no comprehensive study on their frequency and characteristics. In addition, its impact on the QoL has not been fully investigated.

Percentage of patients with each non-motor symptom who reported a decrease in quality of life (QoL)

Credit: Osamu Kano

Non-motor symptoms such as pain, fatigue, and sleep disorders, are observed in patients with ALS and reduce their QoL. Many of the non-motor symptoms are poorly defined with unexplained mechanisms, are underdiagnosed, and remain unreported during clinical consultation. Although the non-motor symptoms of ALS were partially known, there has been so far no comprehensive study on their frequency and characteristics. In addition, its impact on the QoL has not been fully investigated.

Professor Kano Osamu, M.D., Ph.D. and his colleagues investigated the frequency and characteristics of non-motor symptoms in ALS patients. In this regard, a cross-sectional questionnaire survey found that more than 90% of patients had some form of non-motor symptoms. Fatigue was the most common, followed by pain, defecation disorder, sleep disorder, sialorrhea, and sexual problems. In addition, 60–70% of patients declared that these symptoms reduced their QoL. Most importantly, in this study, the frequency of non-motor symptoms other than sialorrhea was not affected based on the ALS Functional Rating Scale-Revised, which assesses the severity of motor symptoms. Therefore, non-motor symptoms may lower QoL even if the motor symptoms of ALS are mild, and should always be considered.

“Since ALS is a motor neuron disease, the focus is naturally on the severity of motor function. However, care should always be taken to keep in mind that even if the motor symptoms are mild, various non-motor symptoms may appear, which may cause distress and thus reduce the patient’s QoL” said Prof. Kano, senior author of the study.



Journal

Acta Neurologica Belgica

DOI

10.1007/s13760-022-02036-6

Method of Research

Observational study

Subject of Research

People

Article Title

Investigation of non-motor symptoms in patients with amyotrophic lateral sclerosis

Article Publication Date

20-Aug-2022

COI Statement

Authors have no COI to declare regarding this press release.

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