ZCCHC4 boosts replication-dependent histone mRNA translation by interacting with eIF3
A newly reported molecular mechanism is drawing attention to one of the most tightly regulated steps in cell biology: the production of histone proteins during...
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KAIST Surface Defects Boost Droplet Formation, Removal, and Heat Transfer by 5.5-Fold
A nanoscale coating that deliberately uses tiny surface “defects” to make water droplets appear faster and leave the surface sooner has delivered a dramatic increase...
Dual-oxygen pancreatic cancer organoids mirror basal-classical diversity, spatial transcriptomics confirms
Pancreatic cancer has long challenged scientists not only because it is difficult to detect and treat, but also because a single tumour can behave like...
Tirzepatide Versus GLP-1 Agonists for Stroke Risk in Atrial Fibrillation and Diabetes
A new study published in Nature Communications is drawing attention to a question at the intersection of diabetes, heart rhythm disorders and stroke prevention: could...
Real-world study examines psychotic complications of subcutaneous foslevodopa/foscarbidopa infusions in 198 patients
A Parkinson’s treatment designed to smooth out the disease’s most disruptive motor fluctuations is now drawing attention to a different clinical challenge: psychotic complications that...
Blood-flow signals from liver vessels direct region-specific liver function through Wnt pathways
For decades, biologists have known that the liver is not a uniform chemical factory. Its cells perform different tasks depending on where they sit within...
Ge/SiGe Quantum-Well Photodetectors Integrated with SiN Waveguides on 200-mm Silicon Wafers
A new approach to building faster, more compact optical sensors could help push silicon photonics beyond the limits of conventional semiconductor platforms. In a study...
Consensus Roadmap Guides Clinical Trials for Rare Childhood CNS Tumors
Rare childhood central nervous system tumours have exposed one of the most stubborn weaknesses in modern oncology: science can move faster than the clinical-trial systems...
Proteomics Links Environmental and Genetic Parkinson’s Models to Purine Metabolism
Parkinson’s disease has long been described as a disorder of dopamine-producing neurons, but a new comparative study suggests that its molecular story may be far...
Wearable Devices Track Activity Rhythms to Reveal Biological Aging Over Time
A smartwatch may be doing far more than counting steps. It may be quietly recording a shifting portrait of how the body ages—minute by minute,...
Succinate Worsens Obesity-Linked Osteoarthritis Through SUCNR1 Activation, Succinylation, and Mitochondrial Dysfunction
A metabolic by-product best known for its role in cellular energy production may be helping obesity turn osteoarthritis into a more aggressive and destructive disease,...
Genetic Basis of Cytokine Autoantibodies Linked to Common Disease Risk
Cytokines are among the immune system’s most powerful molecular messengers. These small proteins coordinate inflammation, guide the development of immune cells and help the body...
How Mitochondria Change During Orthoflavivirus Infections in Humans and Mosquitoes
A new study in npj Viruses is examining how orthoflaviviruses manipulate one of the most dynamic systems inside infected cells: the mitochondria. The article, “Mitochondrial...
How Phages Target Hidden Intracellular Bacteria Behind Persistent Urinary Tract Infections
Urinary tract infections are commonly treated as infections that unfold in an exposed, fluid-filled environment. Yet some of the bacteria responsible for recurrent disease can...
Genomic Study Reveals Betacoronavirus Evolution in Wild Mice and Small Mammals
Wild rodents are emerging as important subjects in the effort to understand how coronaviruses evolve outside human populations. A new study in npj Viruses examines...