• HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
Saturday, August 2, 2025
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Health

NYUAD study finds key protein related to the disease-causing malformation of fat tissue

Bioengineer by Bioengineer
October 14, 2020
in Health
Reading Time: 3 mins read
0
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

This discovery paves the way for future research into treatment of metabolic diseases such as diabetes and obesity

IMAGE

Credit: NYU Abu Dhabi

Abu Dhabi, UAE – October 13, 2020: The impairment of adipogenesis, the process in which fat cells (also known as adipocytes) accumulate to become fat tissue, can lead to many diseases such as diabetes, obesity, and heart conditions. The process of adipogenesis is regulated by a series of signals which program the adipocytes to express specific genes and congregate into adipose tissue.

A team of researchers from NYU Abu Dhabi (NYUAD), led by Associate Professor of Biology Piergiorgio Percipalle in collaboration with Research Assistant Professor Mohamed Al-Sayegh, recently studied the molecular basis of adipogenesis and discovered that the protein actin (a specific variant referred to as β-actin) has an important role in activating the genes which need to be expressed in order to create fat tissue. This further understanding of the adipogenesis process can be applied to future research on diseases caused by malfunctioning fat tissue formation.

In the paper titled β-actin contributes to an open chromatin for activation of the adipogenic pioneer factor CEBPA during transcriptional reprogramming, published in the journal Molecular Biology of the Cell, Percipalle and his team investigates adipogenesis in embryonic mouse tissue to determine how critical the role of β-actin is in the process. It was found that in the fat cells lacking β-actin, the series of genetic signals was impaired, which affected the expression of the genes needed to form fat tissue.

As many diseases are caused by the accumulation of adipose tissue in certain areas, understanding the molecular process of adipose tissue formation is vital. The details of the connection between impaired adipogenesis and metabolic diseases such as diabetes, obesity, and cardiovascular diseases are currently unknown. This study’s findings about the importance of the β-actin protein provide guidance into further tissue-based disease research.

“To understand how to treat diseases, we must have a deeper understanding of the causes of the diseases,” said Percipalle. “This research has shown that the signaling pathway within adipose cells is an intricate system in which β-actin plays an important role. With this new knowledge, we can pursue a closer look into the molecular mechanisms of adipogenesis and find new insights into how to treat related diseases.”

###

About NYU Abu Dhabi

NYU Abu Dhabi is the first comprehensive liberal arts and science campus in the Middle East to be operated abroad by a major American research university. NYU Abu Dhabi has integrated a highly-selective liberal arts, engineering and science curriculum with a world center for advanced research and scholarship enabling its students to succeed in an increasingly interdependent world and advance cooperation and progress on humanity’s shared challenges. NYU Abu Dhabi’s high-achieving students have come from more than 115 nations and speak over 115 languages. Together, NYU’s campuses in New York, Abu Dhabi, and Shanghai form the backbone of a unique global university, giving faculty and students opportunities to experience varied learning environments and immersion in other cultures at one or more of the numerous study-abroad sites NYU maintains on six continents.

Media Contact
Adam Pockriss
[email protected]

Related Journal Article

http://dx.doi.org/10.1091/mbc.E19-11-0628

Tags: BiologyCell BiologyDiabetesGenesGeneticsMetabolism/Metabolic DiseasesMolecular Biology
Share12Tweet8Share2ShareShareShare2

Related Posts

Macrophage-T Cell Interaction Boosts SLAMF1 in TB Defense

Macrophage-T Cell Interaction Boosts SLAMF1 in TB Defense

August 2, 2025
Strawberry Notch 1 Protects Neurons by Regulating Yeats4

Strawberry Notch 1 Protects Neurons by Regulating Yeats4

August 2, 2025

What “And” vs. “Then” Reveal About Hospital Visits: Insights from Online Reviews

August 1, 2025

COVID-19’s Effect on Diagnoses in German Refugee Centers

August 1, 2025
Please login to join discussion

POPULAR NEWS

  • Blind to the Burn

    Overlooked Dangers: Debunking Common Myths About Skin Cancer Risk in the U.S.

    60 shares
    Share 24 Tweet 15
  • Dr. Miriam Merad Honored with French Knighthood for Groundbreaking Contributions to Science and Medicine

    46 shares
    Share 18 Tweet 12
  • Study Reveals Beta-HPV Directly Causes Skin Cancer in Immunocompromised Individuals

    38 shares
    Share 15 Tweet 10
  • Sustainability Accelerator Chooses 41 Promising Projects Poised for Rapid Scale-Up

    35 shares
    Share 14 Tweet 9

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Recent News

Macrophage-T Cell Interaction Boosts SLAMF1 in TB Defense

Strawberry Notch 1 Protects Neurons by Regulating Yeats4

Revolutionary AI Tool Requires Minimal Data to Analyze Medical Images

  • Contact Us

Bioengineer.org © Copyright 2023 All Rights Reserved.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

Bioengineer.org © Copyright 2023 All Rights Reserved.