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Home NEWS Science News Science

NIAID-supported study examines vulnerability of gonorrhea to older antibiotic drug

Bioengineer by Bioengineer
November 17, 2016
in Science
Reading Time: 3 mins read
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WHAT:

A new clinical research study seeks to determine whether a rapid molecular diagnostic test can reliably identify gonorrhea infections that may be successfully treated with a single dose of an older antibiotic, ciprofloxacin. The study will enroll up to 381 men and women diagnosed with untreated Neisseria gonorrhoeae. It is sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. The study is being conducted by the NIAID-funded Sexually Transmitted Infections Clinical Trials Group at four sites: one each in San Francisco, and Philadelphia, and two in Los Angeles.

The Centers for Disease Control and Prevention estimates that more than 800,000 new gonococcal infections occur in the United States each year. Fewer than half of these infections are detected, and antibiotic-resistant infections are a growing problem. People treated for gonorrhea must now receive two drugs–one orally (azithromycin) and another as an injection (ceftriaxone)–to hedge against the possibility that they may harbor a strain resistant to one of the two drugs. The availability of a greater variety of treatments for gonorrhea–and a tool to pinpoint the best treatment option for each individual–would benefit patients and also potentially help slow the development of drug resistance, say the study authors.

In this new trial, scientists will employ a rapid molecular assay using swabbed samples from participants' infection sites to determine whether they are infected with gonorrhea of a specific genetic profile (genotype), gyrA serine 91. Participants with that strain who agree to take part in the study will receive one dose of oral ciprofloxacin (500 mg), and will return for clinical and laboratory assessments within 5 to 9 days to determine if they are cured. Participants who remain infected will be referred for standard treatment.

If the gyrA serine 91 genotype proves to be a reliable marker of vulnerability to ciprofloxacin, healthcare providers may be able to reintroduce ciprofloxacin as a viable treatment for gonorrhea in some cases.

###

The study is being led by principal investigator Jeffrey D. Klausner, M.D., with the David Geffen School of Medicine and Jonathan and Karin Fielding School of Public Health at the University of California, Los Angeles. For more information about the study, see ClinicalTrials.gov using the identifier NCT02961751.

WHO:

Carolyn Deal, Ph.D., chief of the Sexually Transmitted Diseases Branch of NIAID's Division of Microbiology and Infectious Diseases, is available to comment.

CONTACT:

To schedule interviews, please contact Elizabeth Deatrick, (301) 402-1663, [email protected].

NIAID conducts and supports research–at NIH, throughout the United States, and worldwide–to study the causes of infectious and immune-mediated diseases, and to develop better means of preventing, diagnosing and treating these illnesses. News releases, fact sheets and other NIAID-related materials are available on the NIAID website .

About the National Institutes of Health (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit http://www.nih.gov.

NIH…Turning Discovery Into Health ®

Media Contact

Elizabeth Deatrick
[email protected]
301-402-1663
@NIAIDNews

http://www.niaid.nih.gov

############

Story Source: Materials provided by Scienmag

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