• HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
Friday, October 10, 2025
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Biology

New software tool allows sensitive decoding of protein glycosylation

Bioengineer by Bioengineer
April 8, 2022
in Biology
Reading Time: 2 mins read
0
New Software Tool Allows Sensitive Decoding of Protein Glycosylation
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

Glycosylation is a common post-translational modification (PTM) of proteins and plays a crucial role in many biological processes. Many disease biomarkers are glycosylated proteins.

New Software Tool Allows Sensitive Decoding of Protein Glycosylation

Credit: DICP

Glycosylation is a common post-translational modification (PTM) of proteins and plays a crucial role in many biological processes. Many disease biomarkers are glycosylated proteins.

Mass spectrometry-based intact glycopeptide identification can provide information on glycosite and the attached glycans. However, the interpretation of acquired glycopeptide spectra is still challenging.

Recently, a research team led by Prof. YE Mingliang from the Dalian Institute of Chemical Physics (DICP) of the Chinese Academy of Sciences (CAS) has developed a new glycoproteomics software tool, Glyco-Decipher, for the sensitive interpretation of N-glycopeptide mass spectra at high confidence.

This study was published in Nature Communications on April 7.

The researchers found that the fragmentation pattern of the peptide backbone of glycopeptides was not affected by the attached glycans or precursor charge states. And the high similarity of the fragmentation pattern of glycopeptides with identical peptide backbones was utilized to interpret glycopeptide spectra with poor peptide fragmentation.

In addition, the scheme of peptide identification in Glyco-Decipher was glycan database-independent, which enabled the discovery of unexpected glycans that were not present in databases. With the developed monosaccharide stepping method, Glyco-Decipher was able to unveil unexpected glycans with modification moieties in complex systems.

Moreover, the quantification module embedded in the software tool extracted elution profiles of glycopeptides, and thus enabled abundance analysis and functional studies of site-specific glycans.

“Glyco-Decipher is overall a very worthy software tool for glycoproteomics,” commented one of the reviewers.

The study was supported by the National Key Research and Development Program of China, the National Natural Science Foundation of China, and the Youth Innovation Promotion Association of CAS.



Journal

Nature Communications

DOI

10.1038/s41467-022-29530-y

Share12Tweet8Share2ShareShareShare2

Related Posts

BestopCloud: All-in-One Solution for Single-Cell RNA Sequencing

BestopCloud: All-in-One Solution for Single-Cell RNA Sequencing

October 10, 2025
blank

Akkermansia muciniphila Supernatant Fights Resistant Enterococcus Faecalis

October 10, 2025

Bifidobacterium adolescentis SPM2022 Shows Anti-Obesity Effects

October 10, 2025

Fire Yields Enduring Benefits for Bird Populations in Sierra Nevada National Parks

October 10, 2025

POPULAR NEWS

  • Sperm MicroRNAs: Crucial Mediators of Paternal Exercise Capacity Transmission

    1186 shares
    Share 474 Tweet 296
  • New Study Reveals the Science Behind Exercise and Weight Loss

    101 shares
    Share 40 Tweet 25
  • New Study Indicates Children’s Risk of Long COVID Could Double Following a Second Infection – The Lancet Infectious Diseases

    96 shares
    Share 38 Tweet 24
  • Ohio State Study Reveals Protein Quality Control Breakdown as Key Factor in Cancer Immunotherapy Failure

    82 shares
    Share 33 Tweet 21

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Recent News

BestopCloud: All-in-One Solution for Single-Cell RNA Sequencing

Factors Influencing Early Breastfeeding in Côte d’Ivoire

Revolutionary Nanoparticles Enhance Inner Ear Drug Delivery

Subscribe to Blog via Email

Enter your email address to subscribe to this blog and receive notifications of new posts by email.

Join 63 other subscribers
  • Contact Us

Bioengineer.org © Copyright 2023 All Rights Reserved.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

Bioengineer.org © Copyright 2023 All Rights Reserved.