• HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
Tuesday, September 2, 2025
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Health

New medicine shows potential to reduce oral steroid use in severe asthma patients

Bioengineer by Bioengineer
May 25, 2017
in Health
Reading Time: 2 mins read
0
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

Hamilton, ON (May 25, 2017) – A trial led by a McMaster University respirology professor shows promising results for a new medicine for severe asthma patients.

The results of the trial, published this week in the New England Journal of Medicine, demonstrate that patients treated with a potential new medicine and antibody, called benralizumab, were more than four times likely to reduce their usage of oral corticosteroids than those taking a placebo.

"The data is very impressive," said Dr. Parameswaran Nair, the study's lead investigator, professor of medicine at McMaster University, staff respirologist at St. Joseph's Healthcare Hamilton and an AllerGen NCE Investigator.

"In the trial, patients were able to reduce their prednisone dose by as much as 75 per cent, yet they had 70 per cent less exacerbations and 93 per cent less emergency room visits or hospitalizations, while maintaining their lung function."

The phase three ZONDA trial of 220 patients from 12 countries evaluated the effect of benralizumab 30 mg, a monoclonal antibody against the interleukin-5 receptor, on either an eight- or four-week sub-cutaneous dosing regimen for 28 weeks in adult patients with severe asthma receiving a high-dose inhaled corticosteroid and prednisone.

Benralizumab is not an approved medication, but is under regulatory review in several countries, including the United States.

"Benralizumab almost completely removes a white blood cell called eosinophil from the circulation and from lung tissue. Longer term studies with this drug are necessary to be absolutely certain of the safety of this treatment strategy," Nair said.

"However, the results are promising and would likely provide physicians with a useful strategy to treat patients with severe asthma and avoid the dreadful long-term adverse effects of corticosteroids."

Asthma affects 315 million people worldwide. Nearly 10 per cent of asthma patients have severe asthma, which may be uncontrolled despite high doses of standard-of-care asthma medicines and can require the use of chronic oral corticosteroids.

###

The ZONDA trial was funded by AstraZeneca.

Media Contact

Veronica McGuire
[email protected]
905-525-9140 x22169
@mcmasteru

Home

############

Story Source: Materials provided by Scienmag

Share12Tweet7Share2ShareShareShare1

Related Posts

Evaluating Mindfulness Intervention for Self-Injury Recovery

September 2, 2025

New Isoquinoline Derivatives Show Promise as Antifungal Agents

September 2, 2025

Protein Lipoylation: Key to Cancer Metabolic Therapy

September 2, 2025

REM Sleep Quality Linked to Locus Coeruleus Activity

September 2, 2025
Please login to join discussion

POPULAR NEWS

  • blank

    Breakthrough in Computer Hardware Advances Solves Complex Optimization Challenges

    154 shares
    Share 62 Tweet 39
  • Molecules in Focus: Capturing the Timeless Dance of Particles

    143 shares
    Share 57 Tweet 36
  • New Drug Formulation Transforms Intravenous Treatments into Rapid Injections

    117 shares
    Share 47 Tweet 29
  • Do people and monkeys see colors the same way?

    112 shares
    Share 45 Tweet 28

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Recent News

MASL Alters OSCC Cells: Growth, Motility, Morphology Changes

Herbal Extracts Enhance Antibiotic Effects on Resistant Pathogens

Evaluating Mindfulness Intervention for Self-Injury Recovery

  • Contact Us

Bioengineer.org © Copyright 2023 All Rights Reserved.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

Bioengineer.org © Copyright 2023 All Rights Reserved.