• HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
Wednesday, October 22, 2025
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Biology

Lipid raft components offer potential cholesterol-lowering drug target

Bioengineer by Bioengineer
December 20, 2018
in Biology
Reading Time: 1 min read
0
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

Approximately 1 in every 4 deaths in the United States is caused by heart disease, according to the Centers for Disease Control and Prevention. Hypercholesterolemia, or high cholesterol, is a major risk factor for cardiovascular disease. However, cholesterol is also an essential component of cell membranes. Mammals can either synthesize cholesterol or absorb it from food using the intestinal transmembrane protein Niemann-Pick C1-like 1, or NPC1L1. This transporter resides in lipid rafts, membrane microdomains used for cell-cell interaction and cell signaling that are enriched in cholesterol as well as gangliosides — a group of galactose-containing glycolipids.

In a paper in the Journal of Lipid Research, Jin-ichi Inokuchi from Tohoku University in Japan and colleagues show that NPC1L1-dependent intestinal cholesterol uptake requires a particular ganglioside called GM3 and the enzyme that synthesizes it, GM3S. Cholesterol uptake is decreased in GM3S-deficient cells, and GM3S-deficient mice fed a high-cholesterol diet show a lower susceptibility to high blood cholesterol. This research proposes a new viable target for cholesterol reducing therapies.

###

DOI: 10.1194/jlr.M089201

Media Contact
Laurel Oldach
[email protected]
http://dx.doi.org/10.1194/jlr.M089201

Tags: BiochemistryBiologyCholesterolGastroenterologyMetabolism/Metabolic DiseasesNutrition/Nutrients
Share12Tweet8Share2ShareShareShare2

Related Posts

Consumer Demographics Shape Rice Texture and Preference

Consumer Demographics Shape Rice Texture and Preference

October 22, 2025
blank

LET-418/Mi-2 Modulates Intestinal Response to Pathogens in C. elegans

October 22, 2025

How Social Factors Affect Substance Abuse Treatment by Gender

October 22, 2025

Collectors, Not Hunters: The Bone That Calls the ‘Humans Wiped Out Australian Megafauna’ Theory Into Question

October 22, 2025
Please login to join discussion

POPULAR NEWS

  • Sperm MicroRNAs: Crucial Mediators of Paternal Exercise Capacity Transmission

    1272 shares
    Share 508 Tweet 318
  • Stinkbug Leg Organ Hosts Symbiotic Fungi That Protect Eggs from Parasitic Wasps

    304 shares
    Share 122 Tweet 76
  • ESMO 2025: mRNA COVID Vaccines Enhance Efficacy of Cancer Immunotherapy

    141 shares
    Share 56 Tweet 35
  • New Study Suggests ALS and MS May Stem from Common Environmental Factor

    131 shares
    Share 52 Tweet 33

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Recent News

High-Bandwidth Cavity Modulation Enables Advanced Pulse Combs

Heteroatom-Doped Porous Carbon: A Sustainable Counter Electrode

APOE4 Drives Nigral Tau Phosphorylation via Cholesterol

Subscribe to Blog via Email

Enter your email address to subscribe to this blog and receive notifications of new posts by email.

Join 66 other subscribers
  • Contact Us

Bioengineer.org © Copyright 2023 All Rights Reserved.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

Bioengineer.org © Copyright 2023 All Rights Reserved.