• HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
Wednesday, September 24, 2025
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home Headlines

In some genetic cases of microcephaly, stem cells fail to launch

Bioengineer.org by Bioengineer.org
January 31, 2018
in Headlines, Health, Science News
Reading Time: 2 mins read
0
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram
IMAGE

In a very severe, genetic form of microcephaly, stem cells in the brain fail to divide, according to a new Columbia University Medical Center study that may provide important clues to understanding how the Zika virus affects the developing brain.

The study was published August 24 in Nature Communications.

Due to the Zika virus, the world is suffering from its first known epidemic of microcephaly, a devastating brain developmental condition that substantially reduces the number of neurons in the brain, along with brain size and function at birth.

Mutations in a number of human genes have been implicated in causing the relatively rare occurrence of this disease. Mutations in one such gene – NDE1 (referred to as "nood-E") – cause a particularly severe form of microcephaly. The Columbia researchers — David Doobin, an MD/PhD student, Richard Vallee, PhD, professor of pathology and cell biology, and others in Dr. Vallee's lab — reasoned that investigating NDE1's role in microcephaly should provide important clues to the causes of microcephaly in general.

In the study, the researchers found that interfering with NDE1 expression severely inhibited the proliferation of stem cells in the developing rat brain. These stem cells, known as radial glial progenitors (RGPs), undergo rapid repeated divisions over the weeks-to-months-long process of brain development.

Other genes that cause microcephaly are known to impair RGP proliferation, usually by interrupting the cells when they are in the midst of dividing.

The new study found that NDE1 defects can stop RGPs before division even begins at three distinct arrest points. The net result is a complete failure of these cells to divide, explaining the severity of the NDE1-associated microcephaly.

Numerous labs are investigating the effects of Zika on the developing brain, and some studies already suggest that the virus targets RGP cells in the developing brain. Dr. Vallee's lab, along with that of Vincent Racaniello, PhD and Amy Rosenfield, PhD, in Columbia's Department of Microbiology, plan to test for similarities in the damage to neuronal stem cells caused by Zika virus vs. NDE1 mutations.

###

The study is titled, Severe NDE1-Mediated Microcephaly Results from Neural Progenitor Cell Cycle Arrests at Multiple Specific Stages. Additional authors: Shahrnaz Kemal and Tiago J. Dantas (Columbia University Medical Center).

The research was supported by the NIH (R01 HD40182, F30NS095577) and an American Heart Association/American Stroke Association postdoctoral fellowship (15POST25080068).

The authors declare no conflicts of interest.

Columbia University Medical Center provides international leadership in basic, preclinical, and clinical research; medical and health sciences education; and patient care. The medical center trains future leaders and includes the dedicated work of many physicians, scientists, public health professionals, dentists, and nurses at the College of Physicians and Surgeons, the Mailman School of Public Health, the College of Dental Medicine, the School of Nursing, the biomedical departments of the Graduate School of Arts and Sciences, and allied research centers and institutions. Columbia University Medical Center is home to the largest medical research enterprise in New York City and State and one of the largest faculty medical practices in the Northeast. For more information, visit cumc.columbia.edu or columbiadoctors.org.

Media Contact

Lucky Tran, Ph.D.
[email protected]
212-305-3689
@ColumbiaMed

http://www.cumc.columbia.edu

Share13Tweet8Share2ShareShareShare2

Related Posts

AI Enhances Endocytoscopy for Colorectal Lesion Detection

September 24, 2025

Narcissism, FOMO, and Social Media Addiction in College

September 24, 2025

Deep Learning Detects Newborn Pulmonary Hypertension Automatically

September 24, 2025

Teddy Bears as Conservation Tools: Why They Need a Fresh New Look

September 24, 2025
Please login to join discussion

POPULAR NEWS

  • Physicists Develop Visible Time Crystal for the First Time

    Physicists Develop Visible Time Crystal for the First Time

    70 shares
    Share 28 Tweet 18
  • Tailored Gene-Editing Technology Emerges as a Promising Treatment for Fatal Pediatric Diseases

    50 shares
    Share 20 Tweet 13
  • New Study Reveals the Science Behind Exercise and Weight Loss

    50 shares
    Share 20 Tweet 13
  • Scientists Achieve Ambient-Temperature Light-Induced Heterolytic Hydrogen Dissociation

    49 shares
    Share 20 Tweet 12

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Recent News

AI Enhances Endocytoscopy for Colorectal Lesion Detection

Narcissism, FOMO, and Social Media Addiction in College

Deep Learning Detects Newborn Pulmonary Hypertension Automatically

  • Contact Us

Bioengineer.org © Copyright 2023 All Rights Reserved.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

Bioengineer.org © Copyright 2023 All Rights Reserved.