Genes & Cancer | Now on PubMed: Volume 12

BUFFALO, NY- June 16, 2022 – Oncology-focused research papers published in Volume 12 of Genes & Cancer are now on PubMed. Read short previews below about some of the groundbreaking studies published in 2021 by Genes & Cancer. Visit YouTube to watch video previews of studies published by Genes & Cancer.

1. Cover (Research Paper): EZH2 suppresses endogenous retroviruses and an interferon response in cancers

• Origin: Texas, United States
• Institution: The University of Texas Health Science Center
• Quote: “These results uncover the role for NELL2–EZH2 signaling in suppressing endogenous virus-like agents and an antiviral response, and suggest the potential utility of EZH2 inhibitors in enhancing anti-tumor immunity.”

2. Research Paper: Gene signatures of cyclin-dependent kinases: a comparative study in naïve early and advanced stages of lung metastasis breast cancer among pre- and post-menopausal women

• Origin: Karachi, Pakistan
• Institutions: Ziauddin University, Sohail University, Jinnah Postgraduate Medical Center
• Quote: “Collectively, this data revealed that CDKs overexpression levels may predict BC disease progression and provide further rationale for novel anticancer strategies for HER2+ BC cancers.”

3. Research Paper: Key drug-targeting genes in pancreatic ductal adenocarcinoma

• Origin: Saskatchewan, Canada; Kuala Lumpur, Malaysia; New Delhi, India
• Institutions: University of Saskatchewan, University of Malaya, Jawaharlal Nehru University
• Quote: “Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal type of cancer. In this study, we undertook a pairwise comparison of gene expression pattern between tumor tissue and its matching adjacent normal tissue for 45 PDAC patients and identified 22 upregulated and 32 downregulated genes.”

4. Research Paper: Prophylactic cranial irradiation reduces the incidence of brain metastasis in a mouse model of metastatic, HER2-positive breast cancer

• Origin: Texas, United States
• Institution: University of Texas MD Anderson Cancer Center
• Quote: “Prophylactic cranial irradiation (PCI) can reduce the incidence of brain metastasis and improve overall survival in some patients with acute lymphoblastic leukemia or small-cell lung cancer. We examined the potential effects of PCI in a mouse model of breast cancer brain metastasis.”

5. Research Paper: Are molecular tests necessary to diagnose NIFTP?

• Origin: Kielce, Poland
• Institutions: Holycross Cancer Centre, Jan Kochanowski University, 
• Quote: “The aim of this study was to assess the molecular background of NIFTP [noninvasive follicular thyroid neoplasm with papillary-like nuclear features] and to answer the question if the application of revised criteria for NIFTP diagnosis is associated with the lack of oncogenic mutation.”

6. Research Paper: Immunotherapy of prostate cancer using novel synthetic DNA vaccines targeting multiple tumor antigens

• Origin: Philadelphia, United States; Seoul, Korea
• Institutions: The Wistar Institute, Inovio Pharmaceuticals, NanoBio Diagnostics, GeneOne Life Science Inc.
• Quote: “Given the multifocal and heterogeneous nature of prostate cancer, we hypothesized that synthetic DNA vaccines targeting different prostate specific antigens are likely to induce broader and improved immunity who are at high risk as well as advanced clinical stage of prostate cancer, compared to a single antigen approach.”

7. Editorial Paper: Value Added by an Inter-Continental Cancer Consortium

• Origin: Manipal, Mumbai, Kolkata, India; Florida, Kentucky, United States
• Institutions: Manipal Academy of Higher Education, Tata Memorial Centre (ACTREC), Mayo Clinic (Jacksonville), Saroj Gupta Cancer Centre and Research Institute, Markey Cancer Center, University of Kentucky
• Quote: “This is the first collaborative initiative involving multiple government-supported and non-government cancer centers from India and the United States. The purpose of this consortium is to develop meaningful collaborations among the participating faculty of the cancer centers in key areas of cancer research and treatment, education, and community outreach activity.”

8. Research Paper: Pairwise correlation of genes involved in glucose metabolism: a potential diagnostic marker of cancer?

• Origin: Saskatchewan, Canada; Henan Province, China; Kuala Lumpur, Malaysia
• Institutions: University of Saskatchewan, Henan University, University of Malaya
• Quote: “Cancer is a highly malignant disease, killing approximately 10 million people worldwide in 2020. Cancer patient survival substantially relies on early diagnosis. In this study, we evaluated whether genes involved in glucose metabolism could be used as potential diagnostic markers for cancer.”

9. Research Paper: Genomic profiling of DVL-1 and its nuclear role as a transcriptional regulator in triple negative breast cancer

• Origin: Texas, United States
• Institution: Texas Tech University Health Sciences Center
• Quote: “Overall, our findings emphasize the importance of DVL-1 with TNBC [triple-negative breast cancer]-related pathology and identified unexpected gene targets of DVL-1, that may help explain the complexity of aberrant Wnt signaling in cancer.”

 

About Genes & Cancer: Genes & Cancer covers all aspects of the structure and function of oncogenes, growth suppressor and apoptotic genes, their role in signal transduction and the mechanisms by which their expression and function are altered during tumor development. In addition to publishing manuscripts that directly relate to these areas of research, Genes & Cancer also aims to attract papers in the areas of genomics, drug development and systems biology.

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