• HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
Tuesday, October 7, 2025
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Chemistry

Fullerene compounds knock out virus infections

Bioengineer by Bioengineer
September 23, 2019
in Chemistry
Reading Time: 3 mins read
0
IMAGE
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

IMAGE

Credit: Organic and Biomolecular Chemistry

Scientists from the Skoltech Center for Energy Science and Technology and the Institute of Problems of Chemical Physics of RAS in collaboration with researchers from four other Russian and foreign research centers have discovered a new reaction that helps obtain water-soluble fullerene derivatives which effectively combat flu viruses, human immunodeficiency virus (HIV), herpes simplex virus (HSV), and cytomegalovirus (CMV).

Viruses have been affecting social advancement over millennia, often causing vast epidemics wiping out entire cities. Viruses attack every living thing on Earth from higher vertebrates to simple, single-cell life forms, bacteria and even other viruses. Currently, over 90% of human infectious diseases are caused by viruses.

HIV that causes AIDS is one of the most dangerous viruses. According to WHO, the number of HIV-infected patients in Russia has already exceeded 1 million (about 1% of the population) and keeps soaring, making an HIV epidemic an ominous threat to the nation.

Global circulation of seasonal flu viruses that kill 500,000 people worldwide every year is yet another critical public health issue. New varieties of flu viruses often entail high mortality rates (up to 60% for H5N1 and H5N8 avian flu) and are highly resistant to existing drugs.

Modern antiviral drugs extend the lifespan and improve the quality of life, while having quite a few major flaws, such as toxicity, limited bioavailability and development of drug resistance. The circulating sets of flu strains change quickly, reducing the efficiency of the commonly administered anti-flu vaccines. All this makes the search for new classes of antiviral drugs a hot-button issue.

A unique form of carbon, C60 fullerene is shaped like a soccer ball with carbon atoms located at the vertices of its pentagons and hexagons. Although fullerene molecules boast unique biological properties, fullerenes and their classical derivatives are insoluble in water and biological media, making their application in medicine extremely difficult.

Two years ago, a research team led by Skoltech Professor, Pavel Troshin, proposed several effective approaches for the synthesis of water-soluble fullerene derivatives. In their latest study, the researchers discovered a unique new reaction that helped obtain a series of previously unavailable water-soluble fullerene derivatives with high antiviral activity. The mechanism of this unusual transformation of fullerenes was proposed based on the quantum chemical calculations.

“Our latest study focuses on the synthesis of highly effective inhibitors of dangerous viral infections, such as HIV, different varieties of flu, HSV and CMV, using fullerene derivatives as a multifunctional platform. We discovered a unique inversed Arbuzov reaction that allows fine-tuning the antiviral properties of new compounds and establishing fundamental correlations between a compound’s structure and antiviral activity,” explains the first author of the paper and Skoltech PhD student, Olga Kraevaya.

The results of this study open up vast opportunities for developing effective antiviral drugs capable of suppressing virus resistant lines, which will help combat currently untreatable infections.

###

The results of the study were published in the journal Organic & Biomolecular Chemistry and announced on its front cover. This study was made available online in May 2019 ahead of final publication in print in August 2019.

Media Contact
Alina Chernova
[email protected]

Related Journal Article

http://dx.doi.org/10.1039/C9OB00593E

Tags: AIDS/HIVBiochemistryBiologyChemistry/Physics/Materials Sciences
Share12Tweet8Share2ShareShareShare2

Related Posts

Covalent Organic Frameworks: Building Infinite Metal–Organic Structures

Covalent Organic Frameworks: Building Infinite Metal–Organic Structures

October 7, 2025
blank

Next-Generation Perovskite Solar Cells Near Commercialization Milestone

October 7, 2025

Unlocking Clean Energy: Harvesting Hydrogen from Biomass Significantly Cuts Carbon Emissions

October 7, 2025

Innovative Prediction Model Promises Enhanced Reliability for Fusion Power Plants

October 7, 2025
Please login to join discussion

POPULAR NEWS

  • Sperm MicroRNAs: Crucial Mediators of Paternal Exercise Capacity Transmission

    888 shares
    Share 355 Tweet 222
  • New Study Reveals the Science Behind Exercise and Weight Loss

    98 shares
    Share 39 Tweet 25
  • New Study Indicates Children’s Risk of Long COVID Could Double Following a Second Infection – The Lancet Infectious Diseases

    94 shares
    Share 38 Tweet 24
  • Ohio State Study Reveals Protein Quality Control Breakdown as Key Factor in Cancer Immunotherapy Failure

    76 shares
    Share 30 Tweet 19

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Recent News

Study by SFU and Wageningen University Links River Widening to Increased Severity of Floods

Reelin: A Promising Protein for Gut Repair and Depression Treatment

FIU Cybersecurity Experts Unveil Midflight Defense Mechanism to Prevent Drone Hijacking

Subscribe to Blog via Email

Enter your email address to subscribe to this blog and receive notifications of new posts by email.

Join 63 other subscribers
  • Contact Us

Bioengineer.org © Copyright 2023 All Rights Reserved.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

Bioengineer.org © Copyright 2023 All Rights Reserved.