• HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
Friday, August 1, 2025
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News

For tomato genes, one plus one doesn’t always make two

Bioengineer by Bioengineer
April 12, 2021
in Science News
Reading Time: 2 mins read
0
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

IMAGE

Credit: Xingang Wang/Lippman lab, CSHL/2021

Both people and tomatoes come in different shapes and sizes. That is because every individual has a unique set of genetic variations–mutations–that affect how genes act and function. Added together, millions of small genetic variations make it hard to predict how a particular mutation will impact any individual. Cold Spring Harbor Laboratory (CSHL) Professor and Howard Hughes Medical Institute Investigator Zach Lippman showed how genetic variations in tomatoes can influence the way a specific mutation affects the plant. He is working toward being able to predict the effects of mutations on different tomato varieties.

In this study, Lippman and his team used CRISPR, a highly accurate and targeted gene-editing tool, on two tomato genes that control fruit size, SlCV3 and SlWUS. They generated over 60 tomato mutants by removing little pieces of DNA in the promoter regions, areas near the genes that control their expression. In some cases, individual mutations increased the size of the tomatoes by a little bit. Some pairs of mutations did not change fruit size at all. A few synergistic combinations caused a dramatic, unpredicted increase in fruit size. Lippman says:

“The real Holy Grail in all this for crop breeding is predictability. If I mutate this sequence, I’m going to get this effect. Because there is this sea of other variants that nature has accumulated nearby the mutation that you’re engineering, as well as scattered throughout the genome, many of which could be influencing the specific mutation that you’re creating.”

This range of interactions for any two mutations models the consequences of a single mutation occurring in different genetic backgrounds. The effect is comparable to those found in some human diseases, where some people might have certain pre-existing mutations that protect them from disease-causing mutations.

Lippman and his team will continue quantifying how individual and combined mutations affect certain crop traits. So far, they have measured interactions between two individual mutations, but genomes have millions of variations. Lippman hopes to study enough measurable interactions to make breeding more predictable and efficient.

###

Media Contact
Sara Roncero-Menendez
[email protected]

Related Journal Article

http://dx.doi.org/10.1038/s41477-021-00898-x

Tags: Agricultural Production/EconomicsAgricultureBiologyFood/Food ScienceGenesGeneticsPlant Sciences
Share12Tweet8Share2ShareShareShare2

Related Posts

Supporting Me, Limiting You: Unraveling the Complex Interactions Within Intestinal Microbiota

Supporting Me, Limiting You: Unraveling the Complex Interactions Within Intestinal Microbiota

August 1, 2025
Saliva Testing Uncovers Early Indicators of Diabetes and Obesity

Saliva Testing Uncovers Early Indicators of Diabetes and Obesity

August 1, 2025

Blocking Bcl-2 Boosts ER Stress Killing Glioblastoma

August 1, 2025

T Cell Responses: Controlled vs. Natural Schistosome Infection

August 1, 2025
Please login to join discussion

POPULAR NEWS

  • Blind to the Burn

    Overlooked Dangers: Debunking Common Myths About Skin Cancer Risk in the U.S.

    60 shares
    Share 24 Tweet 15
  • Dr. Miriam Merad Honored with French Knighthood for Groundbreaking Contributions to Science and Medicine

    46 shares
    Share 18 Tweet 12
  • Study Reveals Beta-HPV Directly Causes Skin Cancer in Immunocompromised Individuals

    37 shares
    Share 15 Tweet 9
  • Engineered Cellular Communication Enhances CAR-T Therapy Effectiveness Against Glioblastoma

    35 shares
    Share 14 Tweet 9

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Recent News

Supporting Me, Limiting You: Unraveling the Complex Interactions Within Intestinal Microbiota

Saliva Testing Uncovers Early Indicators of Diabetes and Obesity

Blocking Bcl-2 Boosts ER Stress Killing Glioblastoma

  • Contact Us

Bioengineer.org © Copyright 2023 All Rights Reserved.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

Bioengineer.org © Copyright 2023 All Rights Reserved.