• HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
Wednesday, September 24, 2025
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Biology

Fecal transplant throws new light on inflammatory bowel disease

Bioengineer by Bioengineer
June 3, 2022
in Biology
Reading Time: 4 mins read
0
Prof. Sahar El Aidy
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

Inflammatory bowel disease is accompanied by a number of changes in the intestines, such as a change in epithelial permeability, a change in the composition of the microorganisms, and altered levels of antimicrobial substances that are secreted by cells lining the gut. Finding out whether changes are a cause or an effect of the inflammation is difficult. Sahar El Aidy, a microbiologist at the University of Groningen (the Netherlands), together with colleagues from San Diego (US), have now teased out the causal chain leading to inflammation. Their results were published in the journal Gut Microbes on 29 May.

Prof. Sahar El Aidy

Credit: University of Groningen

Inflammatory bowel disease is accompanied by a number of changes in the intestines, such as a change in epithelial permeability, a change in the composition of the microorganisms, and altered levels of antimicrobial substances that are secreted by cells lining the gut. Finding out whether changes are a cause or an effect of the inflammation is difficult. Sahar El Aidy, a microbiologist at the University of Groningen (the Netherlands), together with colleagues from San Diego (US), have now teased out the causal chain leading to inflammation. Their results were published in the journal Gut Microbes on 29 May.

The scientists used mice in which the gene that is responsible for the production of the antimicrobial compound catestatin was knocked out using genetic techniques. In normal mice, catestatin is secreted by cells lining the gut and kills susceptible bacterial strains. The same team, led by Sahar El Aidy, associate professor of Microbiology at the University of Groningen recently described how the composition of gut microbes had changed in these knock-out mice and that signs of inflammation of the intestines were visible.

Metabolites

In their follow-up experiments, the scientists used faecal transplants to find out whether the change in microbial composition is indeed the cause of the inflammation or if it is a result of the observed inflammation. Both knock-out mice and normal mice (wild-type) were given a laxative that removed most of the bacteria from their intestines. ‘We used a laxative, rather than antibiotics, because these drugs could hamper recolonization after the faecal transplant,’ explains El Aidy.

Knock-out mice were given faeces from wild-type mice and vice versa. After two weeks, samples were taken to assess the microbial composition in the intestines. ‘The results showed that the composition had shifted towards that of the donor, which means that the faecal transplants were successful.’ Analysis of the metabolites inside the gut showed that the production of short-chain fatty acids, molecules that affect the function of the gut, was reduced in the knock-out mice. ‘This was largely restored by the faecal transplant from wild-type mice,’ says El Aidy.

Fibrosis

The reduction in short-chain fatty acid production was the result of a change in the microbial community in the intestines, which was in turn caused by the absence of catestatin. ‘Our experiments showed that the epithelial permeability of the intestines, which is higher in the knock-out mice, is restored by the faecal transplant. Also, the extent of fibrosis resulting from inflammation was reduced.’ These results show that the changes in the microbial composition that are caused by the absence of catestatin are responsible for the inflammatory response in the knock-out mice.

Target

This is an important step towards a treatment for inflammatory bowel disease, explains El Aidy: ‘Using transcriptome analysis, we have pinpointed a pattern of gene expression that is associated with the changes that are caused by the removal of catestatin and that was similar to that seen in inflammatory bowel disease. We could link this expression pattern to a number of microbial species, which are, therefore, candidates for being responsible for the changes.’

However, their plan is not to treat patients with faecal transplants. ‘This process has shown contradictory results in humans,’ she says. ‘This might be due to the fact that we didn’t know what constitutes a healthy microbial composition in humans.’ Instead, the results from the new study have given them tools to target specific bacterial strains that are affected by the removal of catestatin. ‘This is what was missing in previous attempts to restore a healthy intestinal microbial community.’

Reference: Pamela González-Dávila*, Markus Schwalbe*, Arpit Danewalia, René Wardenaar, Boushra Dalile, Kristin Verbeke, Sushil K Mahata & Sahar El Aidy: Gut microbiota transplantation drives the adoptive transfer of colonic genotype-phenotype characteristics between mice lacking catestatin and their wild-type counterparts. Gut Microbe, online 29 May 2022
*contributed equally



Journal

Gut Microbes

DOI

10.1080/19490976.2022.2081476

Method of Research

Experimental study

Subject of Research

Animals

Article Title

Gut microbiota transplantation drives the adoptive transfer of colonic genotype-phenotype characteristics between mice lacking catestatin and their wild type counterparts

Article Publication Date

29-May-2022

COI Statement

None

Share12Tweet8Share2ShareShareShare2

Related Posts

blank

Celebrating 100 Years Since the Birth of IVF Pioneer Sir Robert Edwards

September 24, 2025
blank

How Different ALK Fusion Variants Impact Lung Cancer Treatment Success

September 23, 2025

Tracking Motor Skills Across the Lifespan: Using Percentile Reference Curves in Practice

September 23, 2025

Chinese Scientists Uncover Neural Mechanisms Regulating Energy Expenditure in the Arcuate Hypothalamus

September 23, 2025

POPULAR NEWS

  • Physicists Develop Visible Time Crystal for the First Time

    Physicists Develop Visible Time Crystal for the First Time

    69 shares
    Share 28 Tweet 17
  • Tailored Gene-Editing Technology Emerges as a Promising Treatment for Fatal Pediatric Diseases

    50 shares
    Share 20 Tweet 13
  • Scientists Achieve Ambient-Temperature Light-Induced Heterolytic Hydrogen Dissociation

    49 shares
    Share 20 Tweet 12
  • Rapid Spread of Drug-Resistant Fungus Candidozyma auris in European Hospitals Prompts Urgent Warning from ECDC

    48 shares
    Share 19 Tweet 12

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Recent News

Notable Surge in Low- and Alcohol-Free Drink Consumption Among High-Risk UK Drinkers Over Five Years

Study Reveals Regular Exercise ‘Rewires’ Heart-Control Nerves Differently on Left and Right Sides

Even Moderate Alcohol Consumption May Elevate Dementia Risk, Study Finds

  • Contact Us

Bioengineer.org © Copyright 2023 All Rights Reserved.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

Bioengineer.org © Copyright 2023 All Rights Reserved.