• HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
Monday, September 22, 2025
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News

Early treatment may prevent progression to multiple myeloma

Bioengineer by Bioengineer
December 6, 2016
in Science News
Reading Time: 3 mins read
0
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

SAN DIEGO, CA – Early intervention with an immunotherapy-based drug combination may prevent progression of high-risk "smoldering" multiple myeloma to the full-blown disease, according to researchers from Dana-Farber Cancer Institute.

The interim results of a phase 2 clinical trial are to be presented at the 58th annual meeting of the American Society of Hematology in San Diego on December 5, 2016. According to Irene Ghobrial, MD, first author of the report, the findings represent "a promising starting point for the paradigm shift towards early therapeutic intervention in patients with high-risk smoldering multiple myeloma." Ghobrial is also co-principal investigator of the Center for Prevention of Progression of Blood Cancers at Dana-Farber/Brigham and Women's Cancer Center.

The combination of the immunotherapy agent elotuzumab with lenalidomide and dexamethasone was well tolerated, with a low rate of grade 3 or 4 toxicities, the study found.

Individuals are said to have smoldering multiple myeloma if they have evidence of disease in the bone marrow and other pathological signs putting them at risk of developing myeloma, the incurable blood cancer diagnosed in about 30,000 people annually, with 12,650 deaths expected in 2016, according to the American Cancer Society.

Smoldering multiple myeloma patients with high-risk indicators have a 50 percent chance of progressing to symptomatic multiple myeloma within two years. A number of clinical trials are evaluating whether early intervention during the smoldering phase is safe and can prevent myeloma progression.

Ghobrial presented data on 47 of the 50 patients enrolled in the study to date, including 23 patients who completed nine treatment cycles. The drug combination caused tumor shrinkage in 82.6 percent of the latter group of patients, with 34.8 percent complete and very good partial responses.

"Many of these patients are in remission at a median follow-up time of seven months," said Ghobrial. "Some patients have been followed for 23 months, and we haven't seen progression to symptomatic disease in any patient."

"The early results suggest better results than those from a previous trial in which patients received a combination of lenalidomide and dexamethasone," said Ghobrial. "While the interim results are very exciting, I think we need a randomized phase 3 trial before we can make [early intervention] the standard of care."

###

Senior authors of the report are Kenneth C. Anderson, MD, and Paul Richardson, MD, of Dana-Farber.

About Dana-Farber Cancer Institute

From achieving the first remissions in childhood cancer with chemotherapy in 1948, to developing the very latest new therapies, Dana-Farber Cancer Institute is one of the world's leading centers of cancer research and treatment. It is the only center ranked in the top 4 of U.S. News and World Report's Best Hospitals for both adult and pediatric cancer care.

Dana-Farber sits at the center of a wide range of collaborative efforts to reduce the burden of cancer through scientific inquiry, clinical care, education, community engagement, and advocacy. Dana-Farber/Brigham and Women's Cancer Center provides the latest in cancer care for adults; Dana-Farber/Boston Children's Cancer and Blood Disorders Center for children. The Dana-Farber/Harvard Cancer Center unites the cancer research efforts of five Harvard academic medical centers and two graduate schools, while Dana-Farber Community Cancer Care provides high quality cancer treatment in communities outside Boston's Longwood Medical Area.

Dana-Farber is dedicated to a unique, 50/50 balance between cancer research and care, and much of the Institute's work is dedicated to translating the results of its discovery into new treatments for patients locally and around the world.

Media Contact

Anne Doerr
[email protected]
617-632-5665
@DanaFarber

http://www.dfci.harvard.edu

############

Story Source: Materials provided by Scienmag

Share12Tweet8Share2ShareShareShare2

Related Posts

New Strategies for Treating Capecitabine-Induced Hand-Foot Syndrome

September 22, 2025
blank

Exploring Enterococcus faecium Infections in Mexican Children

September 22, 2025

Enhanced Copper Detection with Iron Oxide-Graphite Sensors

September 22, 2025

Micro-LEDs Drive Transparent, Free-Form, Near-Eye Displays

September 22, 2025
Please login to join discussion

POPULAR NEWS

  • blank

    Breakthrough in Computer Hardware Advances Solves Complex Optimization Challenges

    156 shares
    Share 62 Tweet 39
  • Physicists Develop Visible Time Crystal for the First Time

    68 shares
    Share 27 Tweet 17
  • Tailored Gene-Editing Technology Emerges as a Promising Treatment for Fatal Pediatric Diseases

    50 shares
    Share 20 Tweet 13
  • Scientists Achieve Ambient-Temperature Light-Induced Heterolytic Hydrogen Dissociation

    48 shares
    Share 19 Tweet 12

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Recent News

New Strategies for Treating Capecitabine-Induced Hand-Foot Syndrome

Exploring Enterococcus faecium Infections in Mexican Children

Enhanced Copper Detection with Iron Oxide-Graphite Sensors

  • Contact Us

Bioengineer.org © Copyright 2023 All Rights Reserved.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

Bioengineer.org © Copyright 2023 All Rights Reserved.