• HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
Monday, September 29, 2025
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Health

Do men have worse chemotherapy-induced cardiomyopathy than women?

Bioengineer by Bioengineer
May 25, 2017
in Health
Reading Time: 3 mins read
0
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

Prague, Czech Republic – 25 May 2017: Men seem to have worse chemotherapy-induced cardiomyopathy than women despite receiving similar cancer treatments, according to research presented today at EuroCMR 2017.1

"Cancer patients are living longer because of improved treatment but the side effects of treatment include cardiovascular morbidity and mortality," said lead author Dr Iwan Harries, cardiology specialist registrar at Bristol Heart Institute, currently pursuing a PhD on cardiac magnetic resonance (CMR) imaging and cardio-oncology at the University of Bristol, UK.

A 2016 European Society of Cardiology (ESC) position paper on cardio-oncology described female sex as a risk factor for developing cardiotoxicity from chemotherapy.2 Dr Harries said: "The data largely originates from paediatric populations and, in contrast, animal studies report male susceptibility to cardiomyopathy."

This retrospective observational study in adults investigated whether there was a sex effect on chemotherapy-induced cardiomyopathy. The researchers identified all patients over a six year period that received potentially cardiotoxic chemotherapy, were referred for CMR, and were found to have impaired left ventricular function (chemotherapy-induced cardiomyopathy).

Patients were excluded if they had another condition that could have contributed to the cardiomyopathy such as ischaemic heart disease, valvular heart disease, family history of cardiomyopathy, or excess alcohol consumption.

The study included 76 patients (45 women and 31 men). Data was collected on baseline demographics and comorbidities. Details of the cancer treatment were recorded, including the type of chemotherapy, dose of chemotherapy, and the interval between receiving treatment and having the CMR scan. CMR scans provided information on left and right ventricular function, cardiac volumes, and tissue characteristics.

To assess the potential impact of gender on the development of chemotherapy-induced cardiomyopathy, the researchers conducted a multivariate regression analysis correcting for baseline differences between men and women including age, body surface area, comorbidities, and treatment.

The researchers found that both left and right ventricular ejection fraction was significantly lower in men than women, indicating worse performance of the heart. Cardiac volumes and mass were significantly larger in men compared to women, indicating more damage to the heart's structure.

Dr Harries said: "The results of our study suggest that men developed a more severe form of chemotherapy-induced cardiomyopathy than women at follow-up of 8.75 years. Patients receiving anthracycline received on average 240 mg/m2 of doxorubicin or equivalent, a dose which was similar in both men and women."

Previous studies in paediatric populations which found increased risk in females may be explained by the absence of female sex hormones early in life. In adults it may be that female sex hormones are protective. "Previous lab-based research has shown that female adult rat cardiac muscle cells have a survival advantage over male cells when challenged with oxidative stress-induced cell death3, which is one of the proposed mechanisms of chemotherapy-induced cardiomyopathy," Dr Harries explained.

Dr Harries said: "Ours is a preliminary result and large scale trials are needed to confirm our finding that men are more susceptible to chemotherapy-induced cardiomyopathy than women. If confirmed, the implication of these findings is that cardiologists and oncologists could devise individualised treatment and monitoring strategies for their patients that take gender into account."

"Cardio-oncology is a new field of cardiology that is rapidly developing thanks to oncology treatments being more efficacious and oncology patients living longer but with associated cardiovascular morbidity and mortality due to cardiotoxicity," Dr Bucciarelli-Ducci, senior lecturer in cardiology at the University of Bristol and principal investigator of the study concluded.

###

Media Contact

ESC Press Office
[email protected]
@escardio

http://www.escardio.org

############

Story Source: Materials provided by Scienmag

Share12Tweet8Share2ShareShareShare2

Related Posts

Mitochondria: Key Players in Ovarian Ageing Inflammation

September 29, 2025

Placental SERT Gene Linked to Maternal Obesity, Newborn Size

September 29, 2025

Evaluating Caregiver Influences on Youth Eating Disorders

September 29, 2025

Boosting Caregiver Support for Musculoskeletal Patients: Study

September 29, 2025
Please login to join discussion

POPULAR NEWS

  • New Study Reveals the Science Behind Exercise and Weight Loss

    New Study Reveals the Science Behind Exercise and Weight Loss

    85 shares
    Share 34 Tweet 21
  • Physicists Develop Visible Time Crystal for the First Time

    73 shares
    Share 29 Tweet 18
  • Scientists Discover and Synthesize Active Compound in Magic Mushrooms Again

    56 shares
    Share 22 Tweet 14
  • How Donor Human Milk Storage Impacts Gut Health in Preemies

    56 shares
    Share 22 Tweet 14

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Recent News

Genome Analysis Identifies Key Genes for Yak Size

New Simple Test Accurately Predicts Risk of Severe Liver Disease

Precision Molecule Mapping via Structured Illumination Detection

Subscribe to Blog via Email

Enter your email address to subscribe to this blog and receive notifications of new posts by email.

Join 63 other subscribers
  • Contact Us

Bioengineer.org © Copyright 2023 All Rights Reserved.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

Bioengineer.org © Copyright 2023 All Rights Reserved.