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Home NEWS Science News Health

Covariation MS Reveals Protein Regulating Cysteine Catabolism

Bioengineer by Bioengineer
September 17, 2025
in Health
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We next investigated underlying factors that determine the number of significant co-operative and antagonistic interactions for each metabolite in MPCA. The number of protein co-variates with each metabolite did not correlate with the degree of metabolite abundance variation across the DO cohort (Extended Data Fig. 3a). Instead, the number of recapitulated metabolite–protein relationships was positively associated with the number of established biochemical reactions linked to each metabolite (Extended Data Fig. 3b). This suggests that in MPCA, metabolites with higher numbers of protein correlates participate in more biological reactions, serving as substrates, products or cofactors. A prominent example is NAD+, which is a critical redox equivalent and electron carrier used in many biochemical reactions (Fig. 1d,e). We further analysed co-operativity at the pathway level (Extended Data Figs. 3c–i and 4a–e and Supplementary Table 4) and statistical properties of covariation derived from different forms of metabolite–protein relationships (Extended Data Fig. 4f–n). These analyses are provided in the Supplementary Discussion.

Xiao, H., Ordonez, M., Fink, E.C. et al. Covariation MS uncovers a protein that controls cysteine catabolism.
Nature (2025).

bu içeriği en az 2000 kelime olacak şekilde ve alt başlıklar ve madde içermiyecek şekilde ünlü bir science magazine için İngilizce olarak yeniden yaz. Teknik açıklamalar içersin ve viral olacak şekilde İngilizce yaz. Haber dışında başka bir şey içermesin. Haber içerisinde en az 12 paragraf ve her bir paragrafta da en az 50 kelime olsun. Cevapta sadece haber olsun. Ayrıca haberi yazdıktan sonra içerikten yararlanarak aşağıdaki başlıkların bilgisi var ise haberin altında doldur. Eğer bilgi yoksa ilgili kısmı yazma.:

Subject of Research:

Article Title:

Article References:

Xiao, H., Ordonez, M., Fink, E.C. et al. Covariation MS uncovers a protein that controls cysteine catabolism.
Nature (2025). https://doi.org/10.1038/s41586-025-09535-5

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DOI:

Keywords

Tags: biochemical reaction pathwaysbiochemical relationships in MPCAco-operativity in metabolic pathwayscovariation mass spectrometrycysteine catabolism regulationmetabolite abundance variationmetabolite-protein interactionsNAD+ role in metabolismprotein co-variates analysisredox equivalents in metabolismsignificant metabolite relationshipsstatistical analysis of covariation
Tags: **Tags:** covariation mass spectrometrya critical metabolic pathway. This discovery not only deepens our understanding of sulfurcysteine catabolism regulationmetabolite-protein interactionsNAD+ metabolismresearchers have harnessed the power of covariation mass spectrometry (MS) to uncover a previously unknown protein responsible for regulating cysteine catabolismstatistical covariation analysis --- **Breaking News: Covariation Mass Spectrometry Identifies Key Protein in Cysteine Catabolism** In a groundbreaking study published in *Nature*
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