From Cabozantinib to Zanzalintinib: Chemical Tweaks Open New Frontier in Product Hopping
For decades, the pharmaceutical industry’s most familiar strategy for extending the commercial life of a successful medicine has been to ...
Light-triggered proximity labeling identifies SLK as a cancer-specific c-Myc co-regulator
Cancer researchers have identified a previously hidden molecular partnership that may help explain why the protein c-Myc becomes so destructive ...
Coral-inspired scaffold reprograms immune cells to accelerate bone regeneration
A coral-inspired scaffold that combines multi-walled carbon nanotubes with nano-hydroxyapatite has shown promise in restoring bone regeneration in steroid-induced osteonecrosis ...
Giant Virus Genome Catalogue Reveals Vast Diversity and Functional Potential
Giant viruses are rewriting one of biology’s most familiar stories. Once regarded as unusual but relatively isolated curiosities, these oversized ...
STARFISH Reveals Dendritic Translation and Neuroproteasome Degradation of Endogenous Tau
Alzheimer’s disease has long been associated with the accumulation of tau, a neuronal protein that normally helps organize and stabilize ...
Brainstem neurons coordinate the body’s homeostatic responses to cold
Cold is more than an uncomfortable sensation. For mammals, falling environmental temperatures trigger a coordinated emergency programme involving the brain, ...
US Visa Bureaucracy Imposes an Invisible Tax on International Scholars
For international scientists, the cost of working in the United States is often measured in laboratory rent, research materials and ...
Cord Blood Cytokine Patterns May Guide Early Autism Interventions
A newborn’s first blood sample may one day offer scientists an early view of how the developing brain has been ...
National Institute on Aging Workshop Examines Sex Differences in Lifespan Health
A major National Institute on Aging workshop is putting a once-overlooked question at the center of aging science: why does ...
One-step catalyst synthesis converts carbon dioxide into useful methane
Carbon dioxide is often described as a waste product, but researchers are developing increasingly practical ways to turn it into ...
Children’s sensory overload stems from distinct neurobiological mechanisms
Everyday sensations that overwhelm some children—a scratchy clothing tag, the roar of a vacuum cleaner or an unfamiliar smell—may reveal ...
Chonnam National University study finds environmental responsibility boosts financial performance
Consumers may be turning sustainability into a measurable force in corporate finance. A new analysis of 579 publicly listed South ...
Locking therapeutic strategy could make cancer treatment more precise
Although modern cancer treatments can eliminate malignant cells with remarkable efficiency, their lack of perfect selectivity often exposes healthy tissues ...
Unexpected findings reveal new insights into cannabis’s impact on heart health
A randomized clinical trial has produced a surprising finding about cannabis and the heart: habitual users experienced approximately 9% fewer ...
Arizona Water Imports Compared: Sea of Cortez Desalination vs Atmospheric Water Harvesting
Arizona’s water future may hinge on a choice between two radically different ways of importing moisture into one of the ...
Solving the Puzzle of Early Acute Kidney Injury After Pediatric Heart Surgery
Acute kidney injury is one of the most common and consequential complications faced by children after heart surgery, yet it ...
Dresden Researchers Unveil Open-Source Tool Automating Lipid Data Integration
LipidLibrarian Brings the Fragmented World of Lipid Data Into One Open Platform For decades, lipid researchers have faced a deceptively ...
Nature’s Original Bioplastic Doubles as Food for Animals
A tiny marine worm with no mouth, gut, or anus has helped overturn a long-standing assumption about how animals obtain ...
Liver injury calls to poison centers surge nearly 400%
Calls to U.S. poison centers involving liver injuries linked to medications, supplements, alcohol and other foreign substances increased nearly fourfold ...
Teaching AI Antibody Biology Accelerates Drug Discovery
Antibody medicines are often discovered by searching through an overwhelming biological library. Researchers may begin with millions or even billions ...