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Home NEWS Science News Biology

Ancient Genomes Unlock Secrets of East Asian Human Prehistory

Bioengineer by Bioengineer
May 29, 2025
in Biology
Reading Time: 5 mins read
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Population migration, replacement, and the preservation of deeply diverged ancestry in southern East Asia

Ancient Genomes Illuminate Complex Human Prehistory in Southern East Asia

A groundbreaking study recently published in Science has unveiled new dimensions of human prehistory in southern East Asia by analyzing 127 ancient genomes from Yunnan, China, spanning a broad temporal range between 7,100 and 1,400 years before present. Led by Prof. Fu Qiaomei from the Institute of Vertebrate Paleontology and Paleoanthropology at the Chinese Academy of Sciences, this research integrates advanced genome-wide sequencing techniques and robust bioinformatics analyses to reconstruct the deep evolutionary history of populations in this pivotal geographic region. The findings underscore southern East Asia’s critical role in shaping the genetic landscape of contemporary Tibetan and Austroasiatic-speaking populations, thus offering an expanded narrative for human migration and interaction over the last several millennia.

Among the most striking revelations is the discovery of a genetically unique 7,100-year-old individual from Yunnan, whose genome exhibits as profound a divergence from present-day East Asian populations as some 40,000-year-old individuals from northern China’s Beijing area. This startling genetic distinctiveness has led researchers to define a previously uncharacterized ancestral lineage, termed “Xingyi ancestry.” Phylogenetic reconstructions and population structure analyses indicate that this group represents deeply diverged Asian ancestry, revealing complex demographic layers that operated in East Asia far earlier than previously recognized. The genomic isolation of this lineage suggests ancient population substructure and highlights southern China as an enduring refuge for archaic genetic lineages.

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Intriguingly, comparative genomic assessments reveal that although the Xingyi-related individual is markedly distinct from most modern East Asians, the lineage shares genetic affinities with extant populations inhabiting the Qinghai-Tibet Plateau. This finding aligns with prior studies documenting the unique genetic adaptations and heritage of plateau populations, who exhibit distinct allelic variants associated with high-altitude adaptation and other phenotypic traits unprecedented in lowland groups. The genomic connectivity between the ancient southern East Asian individuals and Tibetan Plateau populations thus deepens our understanding of the evolutionary processes that have shaped human diversity in high-altitude environments and points to a complex web of human movement and admixture in this region during the Holocene.

The persistence of Xingyi ancestry into the Holocene epoch underscores the longevity of ancient genetic lineages in southern East Asia prior to their eventual decline or replacement. Notably, the study contextualizes this ancestry within the broader chronology of human settlement by referencing an 11,000-year-old individual from Longlin, Guangxi. Genomic data from this earlier sample also exhibit elements of Xingyi-related ancestry, suggesting that this lineage was once more widespread across southwestern China. However, evidence indicates that such genetic components diminished significantly in subsequent populations from Guangxi, reflecting dynamic population turnover and displacement linked to shifting ecological and cultural landscapes during this interval.

Beyond the singular case of the Xingyi lineage, the research team also conducted a comprehensive genome-wide analysis of ancient human remains from central Yunnan dated between 5,100 and 1,400 years ago. This cohort displays a distinct genetic ancestry, divergent from both northern and southern East Asian groups, signaling the presence of a unique population branch within the region. Population divergence time estimates suggest that this lineage separated from other East Asian ancestries at least 19,000 years ago, shedding light on the deep prehistoric separation and evolution of human groups in China. This prolonged genetic isolation likely contributed to the formation of genetically and culturally distinct populations prior to known historical periods.

The genetic profile of these central Yunnan individuals also exhibits close affinity to Austroasiatic-speaking populations, who are distributed today across Southeast Asia, parts of South Asia, and southern China. This connection is of particular interest to anthropologists and linguists, given ongoing debates about the origins and expansion patterns of Austroasiatic languages. Intriguingly, the presence of Austroasiatic-related genetic ancestry in central Yunnan long predates the advent of agricultural practices, challenging the prevailing hypothesis that the spread of Austroasiatic speakers was primarily driven by early farming expansions. Instead, this suggests that Austroasiatic linguistic and genetic heritage may have an older, deeper foundation in southern East Asia’s pre-agricultural period.

This finding has profound implications for understanding the complex interplay between subsistence strategies and population expansions in prehistoric Asia. The continuous genetic record spanning from 5,100 to 1,400 years ago offers the oldest direct genomic evidence associated with Austroasiatic-related ancestry, indicating a longstanding presence in the region. Consequently, central Yunnan, along with the adjacent Red River Valley, emerges as a crucial geographical nexus for unraveling the population history and dispersal of Austroasiatic-speaking peoples. These insights provide a critical framework for future interdisciplinary studies integrating genetics, archaeology, and historical linguistics.

The study further elucidates the interactions between populations in western and southeastern Yunnan, revealing that northern East Asian ancestries contributed differentially across these subregions. Genetic data show that populations with northern East Asian heritage had a notable impact on western Yunnan groups, whereas distinct northern East Asian genetic influence was found in southeastern Yunnan. These patterns suggest complex migration routes and admixture events, highlighting the layered and dynamic demographic history across relatively small but ecologically and culturally diverse landscapes within Yunnan province.

Taken together, the authors emphasize that Southwest China constitutes a key hotspot for prehistoric human migration, cultural interchange, and genetic diversification. The recovered ancient genomes provide unprecedented resolution into the genetic makeup of past populations, offering a window into the demographic processes that have shaped the mosaic of ethnic and linguistic diversity present in Yunnan today. Such deep genetic heterogeneity also resonates with archaeological evidence for diverse cultural complexes in the region, underscoring the importance of integrating genetics within broader anthropological narratives.

Moreover, the findings significantly expand our understanding of human population dynamics across a wide geographic swath stretching from the Qinghai-Tibet Plateau to Southeast Asia. By reconstructing the temporal and spatial trajectories of ancient ancestries, the study reveals previously unappreciated pathways of population persistence, replacement, and interaction that transcend ecological and linguistic boundaries. This expanded perspective reshapes narratives of East Asian human evolution by emphasizing the persistence of archaic lineages, their admixture with incoming migrants, and their lasting legacy in shaping contemporary genetic diversity.

The application of state-of-the-art ancient DNA retrieval and genome sequencing methods was essential for uncovering these insights. The technical rigor involved isolating high-quality genetic material from archaeological remains exemplifies the challenges and advancements in paleogenomics. The team employed stringent contamination controls, cutting-edge bioinformatics pipelines, and comparative analyses across broad temporal gradients to map genetic variation with high confidence. These methodological strengths lend robustness to the study’s conclusions and set a new standard for future research on East Asian prehistory.

In summary, Prof. Fu Qiaomei and colleagues’ research provides a transformative view of the genetic history of southern East Asia. Their work not only identifies previously hidden ancestral lineages such as the Xingyi ancestry but also contextualizes the emergence and interactions of modern East Asian populations within a deep time framework. This comprehensive genomic data underscores the complexity and richness of human evolution in this critical region, providing a vital link between early Holocene hunter-gatherers, the origins of Tibetan and Austroasiatic groups, and the broader tapestry of East Asian diversity. These findings open new directions for multidisciplinary explorations into the genetic, archaeological, and cultural histories that continue to define human societies in Asia and beyond.

Subject of Research: Human population genetics, ancient genomics, East Asian prehistory.

Article Title: Population migration, replacement, and the preservation of deeply diverged ancestry in southern East Asia.

Web References: https://dx.doi.org/10.1126/science.adq9792

Image Credits: Image by Prof. FU Qiaomei’s group.

Keywords: Human evolution, History of life, Paleontology.

Tags: ancient genomes analysisAustroasiatic-speaking populationsbioinformatics in archaeologydemographic layers in ancient populationsEast Asian human prehistoryevolutionary history of East Asiansgenetic diversity in East Asiagenomic sequencing techniqueshuman migration in southern East AsiaTibetan genetic heritageXingyi ancestry discoveryYunnan ancient populations

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