Acta Pharmaceutica Sinica B (APSB) was founded with the goal of creating a global high-level forum centred around drug discovery and pharmaceutical research/application. APSB was included by Chemical Abstracts in 2011, accepted by PubMed Central in 2015, indexed by Science Citation Index in 2017 and has evolved to become one of the most important international journals in the field of pharmaceutical sciences.
APSB is a monthly journal, in English, which publishes significant original research articles, rapid communications and high-quality reviews of recent advances in all areas of pharmaceutical sciences — including pharmacology, pharmaceutics, medicinal chemistry, natural products, pharmacognosy, pharmaceutical analysis and pharmacokinetics.
Articles of interest in this issue include:
Data-driven engineering framework with AI algorithm of Ginkgo Folium tablets manufacturing by Lijuan Ma, Jing Zhang, Ling Lin et al. (https://doi.org/10.1016/j.apsb.2022.08.011). The innovative data-driven engineering strategy integrated artificial intelligence (Al) algorithms was proposed for process capability and end-to-end quality traceability of intelligent pharmaceutical manufacturing.
Entinostat, a class I selective histone deacetylase inhibitor, plus exemestane for Chinese patients with hormone receptor-positive advanced breast cancer: A multicenter, randomized, double-blind, placebo-controlled, phase 3 trial by Binghe Xu, Qingyuan Zhang, Xichun Hu et al. (https://doi.org/10.1016/j.apsb.2023.02.001). In this multicenter phase III trial in Chinese patients with hormone receptor-positive advanced breast cancer, entinostat plus exemestane significantly prolonged the progression-free survival compared to placebo plus exemestane (HR = 0.76, P = 0.046).
Click chemistry extracellular vesicle/peptide/chemokine nanocarriers for treating central nervous system injuries by Huitong Ruan, Yongfang Li, Cheng Wang et al. (https://doi.org/10.1016/j.apsb.2022.06.007). Click chemistry extracellular vesicle/peptide/chemokine nanomissiles repair central nervous systems (CNS) injuries by targeting blood vessels, recruiting neural stem cells (NSCs) and inducing their differentiation into neurons.
Special Column: Delivery Nanotechnologies to Modulate the Immune System and Combat Inflammation and Infection Guest Editors: Wei He, Chenjie Xu, Alejandro Sosnik
Cellular nanovesicles for therapeutic immunomodulation: A perspective on engineering strategies and new advances
Endong Zhang, Philana Phan, Zongmin Zhao
Localized delivery of nanomedicine and antibodies for combating COVID-19
Bin Tu, Yanrong Gao, Xinran An, Huiyuan Wang, Yongzhuo Huang
Self-therapeutic metal-based nanoparticles for treating inflammatory diseases
Ruifang Han, Yu Xiao, Qianqian Bai, Chung Hang Jonathan Choi
Polymeric nanocarriers for nose-to-brain drug delivery in neurodegenerative diseases and neurodevelopmental disorders
Rania Awad, Avi Avital, Alejandro Sosnik
Cell-derived nanovesicles from mesenchymal stem cells as extracellular vesicle-mimetics in wound healing
Yub Raj Neupane, Harish K. Handral, Syed Abdullah Alkaff, Wei Heng Chng, … Giorgia Pastorin
Glycan targeting nanoparticle for photodynamic immunotherapy of melanoma
Yonghyun Choi, Wooic Son, Youngpin Han, Jayoung Chae, … Jonghoon Choi
Other articles include:
The traditional Chinese medicines treat chronic heart failure and their main bioactive constituents and mechanisms
Jie Chen, Xiaohong Wei, Qian Zhang, Yuzhuo Wu, … Sheng Lin
The hippo kinases MST1/2 in cardiovascular and metabolic diseases: A promising therapeutic target option for pharmacotherapy
Yunfei Yin, Mingyue Tan, Lianhua Han, Lei Zhang, … Hongxia Li
The dichotomous role of immunoproteasome in cancer: Friend or foe?
Boya Chen, Haiying Zhu, Bo Yang, Ji Cao
Click chemistry and drug delivery: A bird’s-eye view
Shameer M. Kondengadan, Shubham Bansal, Ce Yang, Dongning Liu, … Binghe
Neuron stem cell NLRP6 sustains hippocampal neurogenesis to resist stress-induced depression
Chuanfeng Tang, Qiaona Wang, Jingyan Shen, Congying Wang, … Lingdong Kong
The host-targeting compound peruvoside has a broad-spectrum antiviral activity against positive-sense RNA viruses
Kan Xing Wu, Thinesshwary Yogarajah, Marcus Wing Choy Loe, Parveen Kaur, … Justin Jang Hann Chu
Identification of anti-Mycobacterium tuberculosis agents targeting the interaction of bacterial division proteins FtsZ and SepFe
Hongjuan Zhang, Ying Chen, Yu Zhang, Luyao Qiao, … Jiandong Jiang
Universal chimeric Fcγ receptor T cells with appropriate affinity for IgG1 antibody exhibit optimal antitumor efficacy
Wen Zhu, Yang Wang, Liangyin Lv, Hui Wang, … Huili Lu
UHRF1/DNMT1–MZF1 axis-modulated intragenic site-specific CpGI methylation confers divergent expression and opposing functions of PRSS3 isoforms in lung cancer
Shuye Lin, Hanli Xu, Lin Qin, Mengdi Pang, … Jiaqiang Huang
Enhancement of oligodendrocyte autophagy alleviates white matter injury and cognitive impairment induced by chronic cerebral hypoperfusion in rats
Huiyang Wang, Yueyang Liu, Zhenkun Guo, Minghui Cui, … Chunfu Wu
Novel STING-targeted PET radiotracer for alert and therapeutic evaluation of acute lung injury
Duo Xu, Fan Yang, Jiayao Chen, Tianxing Zhu, … Dan Li
Discovery and identification of EIF2AK2 as a direct key target of berberine for anti-inflammatory effects
Wei Wei, Qingxuan Zeng, Yan Wang, Xixi Guo, … Danqing Song
8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases
Damijan Knez, Daniel Diez-Iriepa, Mourad Chioua, Andrea Gottinger, … José Marco-Contelles
Sequential delivery of PD-1/PD-L1 blockade peptide and IDO inhibitor for immunosuppressive microenvironment remodeling via an MMP-2 responsive dual-targeting liposome
Chuan Hu, Yujun Song, Yiwei Zhang, Siqin He, … Huile Gao
Single-shot AAV-vectored vaccine against SARS-CoV-2 with fast and long-lasting immunity
Fuhua Wu, Shuang Luo, Yongshun Zhang, Yangsen Ou, … Xun Sun
Genomic, transcriptomic, and epigenomic analysis of a medicinal snake, Bungarus multicinctus, to provides insights into the origin of Elapidae neurotoxins
Jiang Xu, Shuai Guo, Xianmei Yin, Mingqian Li, … Shilin Chen
Berberine improves central memory formation of CD8+ T cells: Implications for design of natural product-based vaccines
Mingyan Li, Yaling Wang, Lingzhi Zhang, Changxing Gao, … Qing Zhu
Nimbolide targeting SIRT1 mitigates intervertebral disc degeneration by reprogramming cholesterol metabolism and inhibiting inflammatory signaling
Yun Teng, Yixue Huang, Hao Yu, Cenhao Wu, … Jun Zou
Supramolecular approaches for insulin stabilization without prolonged duration of action
Rolande Meudom, Yanxian Zhang, Michael A. VandenBerg, Lei Zou, … Danny Hung-Chieh Chou
Letter to the editor
A potentially serious adverse effect of GLP-1 receptor agonists
Jinmiao Lu, Hao Liu, Qingtong Zhou, Ming-Wei Wang, Zhiping Li
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The Journal of the Institute of Materia Medica, the Chinese Academy of Medical Sciences and the Chinese Pharmaceutical Association.
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Impact Factor: 14.907
JIF without self-citation: 13.885
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