(Helmholtz Zentrum München – German Research Center for Environmental Health) Scientists at Helmholtz Zentrum München have discovered new details about the UHRF1 protein. UHRF1 catalyses particular steps that are required for marking DNA with epigenetic modifications that suppress parts of the genome. As reported in Molecular Cell, the molecule may serve as a target for drug therapies because it is produced at elevated levels in cancer cells.
A new piece to the puzzle sheds light on how UHRF1 regulates gene activity
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