Genetic evidence challenges the obesity paradox in cardiovascular-kidney-metabolic disease
A combined epidemiological and genetic analysis finds that genetic susceptibility to higher BMI shows a linear adverse association with mortality, ...
Tag: UK Biobank
New matching framework weaves polygenic risk into the search for disease causality
A new method called PRIMA incorporates polygenic risk scores into propensity score matching to help disentangle causal disease relationships from ...
Presarcopenia in older adults flags higher osteoporosis risk in UK Biobank study
A prospective UK Biobank study finds that older adults with presarcopenic phenotypes show a suggestively higher risk of incident osteoporosis, ...
Chronic widespread pain linked to higher cardiovascular risk in type 2 diabetes
A UK Biobank cohort study of over 17,000 people with type 2 diabetes found that chronic widespread pain was associated ...
Exome and Array Data Combined Rival Whole-Genome Sequencing for Most Pharmacogenes
Combining whole-exome sequencing with imputed genotyping array data matched whole-genome sequencing results for 25 of 33 pharmacogenes in UK Biobank ...
Sleeping Too Little or Too Long Linked to Higher Brain Bleed Risk in Large UK Cohort
A prospective UK Biobank cohort study of 314,236 adults found that both short and long habitual sleep duration were associated ...
Average human genome characterised for first time from nearly one million sequences
A University of Exeter-led survey of nearly one million whole genomes shows everyone carries millions of variants, including rare disease-linked ...
Chemical plant proximity linked to diabetic complications in prospective UK cohort
A prospective analysis of 9,963 UK Biobank participants found that closer residence to chemical plants was associated with higher risks ...
Adiposity measures offer only modest cardiovascular prediction gains
A UK Biobank cohort study found that alternative adiposity indices provided only small, outcome-specific gains in cardiovascular risk prediction over ...
Plasma Protein Signatures Predict Rheumatoid Arthritis Years Before Symptoms Appear
A UK Biobank study of 47,537 people identified 213 plasma proteins linked to rheumatoid arthritis onset and built a deep ...
Hours in the Sun Linked to 36 Diseases in Massive UK Biobank Analysis
A UK Biobank study of 281,282 adults links longer outdoor sunlight exposure to higher risks of melanoma, obesity, and cerebrovascular ...
Genetically Higher Bone Mineral Density Linked to Lumbar Spinal Stenosis Risk
A Mendelian randomization and UK Biobank cohort study found that genetically proxied higher bone mineral density was associated with modestly ...
The X Chromosome That Vanishes: How Aging Women’s Blood Cells Lose a Sex Chromosome
A sweeping review of population-scale genomic data reveals that loss of the X chromosome is the most common mosaic chromosomal ...
Blood Proteins Predict ALS Years Before Symptoms Strike
A large prospective UK Biobank study of 52,584 adults identified nine plasma proteins, led by neurofilament light chain, that predict ...
Nearly 38% of Danes Live With Chronic Disease Linked to Flawed Tissue Scaffolding
A nationwide Danish register study of 331 chronic extracellular matrix-related conditions finds that 38% of the population lives with one ...
AlphaGenome Atlas Predicts Effects of Billions of DNA Changes
AlphaGenome Atlas provides AI-generated predictions for more than 9 billion possible single-letter DNA changes across hundreds of human cell types ...
Higher eGDR linked to lower gastrointestinal cancer mortality in UK cohort
A prospective UK Biobank study found that higher estimated glucose disposal rate was associated with lower gastrointestinal cancer mortality, but ...
Irregular sleep linked to lower fluid intelligence in UK Biobank cohort
An exploratory UK Biobank cohort study found that greater night-to-night sleep variability was associated with lower subsequent fluid-intelligence scores, but ...
Knee osteoarthritis linked to higher osteoporosis risk in 406,810-person cohort
A prospective study of 406,810 UK Biobank participants found that knee osteoarthritis was independently associated with a 22% higher hazard ...
fastGxE maps gene–environment interactions across UK Biobank traits
fastGxE found 25 candidate gene–environment interaction loci across 99 UK Biobank traits, including 16 loci not previously associated with these ...
