Loquat’s Drought Secrets: 21 Heat Shock Genes Reveal a Survival Switch
Researchers have identified 21 heat shock transcription factor genes in loquat and found that EjHsfB2a is consistently switched on under ...
Tag: transcription factors
AI Decodes the Hidden Grammar of the Genome’s Master Organizer CTCF
A new computational framework called DeCTCF uses AI-predicted epigenomic features to sort more than 236,000 CTCF binding sites into 20 ...
Symbiotic Bacteria Carry a Hidden Arsenal of Gene-Controlling Weapons, Structural Study Reveals
A structural analysis using AlphaFold2 reveals that symbiotic rhizobial effectors are modular proteins carrying hidden DNA- and RNA-binding domains, including ...
Blood Cells From 80-Year-Olds Rejuvenated Into Brain Cells With Molecular Age Under 20
University of Bonn researchers directly reprogrammed red blood cell precursors from elderly donors into neural stem cells whose epigenetic clocks ...
One Obesity Gene Variant Rewires Nearly 100 Genes in Fat Cells, Study Finds
Researchers combined single nucleus RNA-sequencing with GWAS and UK Biobank data to show that an obesity-linked variant in SREBF1 allele-specifically ...
Wheat’s Hidden Salt-Stress Genes: Scientists Map the ARID Family From Root to Grain
A genome-wide study of wheat has identified twenty ARID transcription factor genes, showing that they evolved largely through segmental duplication ...
How a Plant Hormone Helps Tomatoes Beat the Heat: New Clues From the Photosynthesis Genes
New research shows that the plant hormone 2,4-epibrassinolide protects tomato photosynthesis under heat stress by preserving chloroplast structure and activating ...
Ancient Jumping Genes Help Explain How DNA Variants Shape the Human Cortex
A massively parallel reporter assay of 9,092 cortical-structure-associated variants reveals that Alu retrotransposons, Wnt signaling and transcription factor expression jointly ...
Black Sorghum Genome Cracked: New Reference Reveals Secrets of Rare Antioxidant-Rich Grain
Scientists have assembled the first reference genome of black pericarp sorghum Tx3362 and mapped the genes and transcription factors behind ...
Blood Cells Rewound: Direct Neural Conversion Slowly Erases Epigenetic Age
Direct conversion of human blood cells into neural stem cells erases nearly all epigenetic age over a protracted fifty-day process ...
Cancer Cells Turn Fat Factories: SOX9 Fuels Colorectal Cancer Spread Through Lipid Rewiring
New research reveals that the transcription factor SOX9 drives colorectal cancer metastasis by directly activating the fat-synthesizing enzyme FASN, and ...
How a Rare Medicinal Plant Builds Its Silkworm-Like Rings: Multi-Omics Study Reveals the Mechanism
A multi-omics study reveals that the prized silkworm-like rings of the medicinal plant Notopterygium incisum form through uneven secondary growth, ...
Gliding Mammals Evolved the Same Skill Through Different Genetic Routes
A genomic comparison of three independently evolved gliding mammal lineages shows that different regulatory DNA regions can converge on similar ...
Two Master Genes That Decide Whether Blood Cells Are Born or Turn Cancerous
A new review details how the Runx1 and Gata2 transcription factors architect the epigenetic landscape of blood formation and how ...
Hidden RNA Switches May Explain How Eucalyptus Leaves Turn Red Under Stress
A new full-length transcriptome study reveals extensive alternative splicing and identifies three MYB113 genes, including the unusual MYB113c, as regulators ...
How a Shifting Cast of Transcription Factors Rewires Androgen Signaling in the Aging Brain
New research shows that Alzheimer's disease disrupts androgen receptor signaling in the male brain by dismantling the collaborative transcription factor ...
Cell-Free DNA Reflects Tumor Transcription Factor Activity
In a groundbreaking study, Tamaki et al. have unveiled a novel method utilizing cell-free DNA (cfDNA) to explore the activities ...
